A-PRF and CGF in Palatal Donor Site Healing

Effects on Patients' Postoperative Morbidity and Donor Site Wound Healing of A-PRF and CGF Application After Free Gingival Graft Harvesting: A Comparative Randomized Clinical Trial

The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.

The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.

Fourty-five patients who underwent FGG harvesting were randomly assigned to three groups: (1) control group (n=15), receiving only a sterile gelatin sponge; (2) A-PRF group (n=15), receiving A-PRF clot membranes; and (3) CGF group (n=15), receiving CGF clot membranes at the donor site. The epithelization rate, color match, and sensation scores of the palatal wound were assessed at 1, 2, 3, and 4 weeks postoperatively. Pain levels, analgesic consumption, and bleeding time were self-reported by patients for the first 7 days of healing.

Inclusion Criteria:

• at least 18 years old,
• without systemic or periodontal diseases,
• without medical contraindications to periodontal surgery
• with full-mouth plaque control scores ≤ 20%
• Gingival index scores ≤ 1

Exclusion Criteria:

• smoking habits,
• diabetes mellitus,
• pregnancy or lactation,
• removable upper denture,
• regular medication that could interpose the healing process, undergoing bisphosphonate therapy, history of radiation therapy of the jaws, and follow-up consults