PRF for Accelerating Palatal Healing

The Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial

Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.

125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.

Inclusion Criteria:

• no contraindications for periodontal surgery;
• full-mouth plaque score of <10%
• full-mouth bleeding score of <15%.

Exclusion Criteria:

• previously undergone surgery for a graft harvested from the palate
• presence of systemic disease or taking medication known to interfere with periodontal health
• smokers
• possible coagulation disorders