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Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.
125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Platelet Rich Fibrin | Experimental | PRF was laid directly on the palatal wound immediately after harvesting the tissue graft and stabilized |
|
| Butyl cyanoacrylate | Active Comparator | Butyl cyanoacrylate was directly applied on the palatal wound after harvesting the tissue graft |
|
| Wet Gauze | Placebo Comparator | Wet Gauze was placed for 1 minute on the palatal wound after harvesting the tissue graft |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet Rich Fibrin | Other | Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded after PRF placing on palatal wounds. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Epithelialization | Assessed according to the toluedine blue coloring | One month |
| Measure | Description | Time Frame |
|---|---|---|
| Sensibility disorders | visual analogue scale scores | One month |
| feeding habits | visual analogue scale scores | One month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Onur Ozcelik, Ph D | Cukurova University, Professor | Study Director |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| Butyl cyanoacrylate | Other | Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded after Butyl Cyanoacrylate application on palatal wounds. |
|
| Wet gauze | Other | Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded after wet gauze pressure on palatal wounds. |
|
| Delayed bleeding | Bleeding assesment for post-operative one week | 1 week |
| Immediate Bleeding | Bleeding assesment for post-operative one hour | 1 hour |
| Pain | Visual Analague Scale scores | 3 months |
| D055093 |
| Periodontal Atrophy |