The objectives of this study were to clarify how environmental factors such as air pollution affect the occurrence and development of gastric cancer; to identify patient-specific macrogenomic markers of gastric cancer; and to investigate the mechanism of gastric cancer development based on environmental factors and macrogenomic data.

Inclusion Criteria:

• age ≥ 18 years;
• patients with preoperative diagnosis of gastric cancer confirmed by pathologic biopsy;
• no chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
• willing to participate in the study and sign the informed consent form;
• complete clinical data.

Exclusion Criteria:

• concurrent primary malignant tumor other than gastric cancer;
• patients with systemic diseases, such as severe cardiopulmonary;
• insufficiency, that affect the choice of treatment plan;
• not suitable for enrollment as assessed by the investigator;
• incomplete clinical data.

Patients with preoperative diagnosis of gastric cancer confirmed by pathologic biopsy and 1:1 participants with no history of malignancy were included in the study.

Data sharing is not permitted by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University.