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Colorectal cancer is one of the malignant tumours with high morbidity and mortality worldwide, posing a serious threat to human health. In recent years, the incidence of colorectal cancer has been on the rise with changes in lifestyle and dietary habits. Although some progress has been made in treatments such as surgery, chemotherapy and radiotherapy, however, the early diagnosis, prognosis assessment and personalised treatment of colorectal cancer still face great challenges. Therefore, it is of great academic value and practical significance to deeply explore the influencing factors of colorectal cancer occurrence, development and its prognosis, especially the research on environmental factors and metabolomics.
In this study, investigators collected clinical information, blood, urine and stool for ambient air pollution analysis, blood metabolomics analysis and stool macro-genetic sequencing by including patients from healthy control and colorectal cancer groups, respectively. Environmental factors, metabolomics and intestinal microbiota data were integrated and analysed to screen for indicators that play a key role in colorectal cancer development and construct a colorectal cancer prediction model.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the control group | Adults with no history of malignancy and willing to participate in this study. | ||
| the colorectal cancer group | Patients with preoperative diagnosis of colorectal cancer confirmed by pathological biopsy. |
| |
| the colorectal adenoma group | Patients with preoperative diagnosis of colorectal adenoma confirmed by colonoscopy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| colorectal cancer | Diagnostic Test | Patients diagnosed with colorectal cancer by pathological biopsy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of postoperative complications | Surgical complications was defined as any postoperative complication occurring during the postoperative hospitalisation period. | From date of surgery until the date of first documented postoperative complication, assessed up to 2 months after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Overall survival was defined as time from date of diagnosis until the date of death from any cause or or loss to follow-up. | From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months. |
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Inclusion Criteria:
Healthy control group:
Gastric cancer group:
Exclusion criteria:
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All adult patients diagnosed with colorectal cancer and undergoing radical surgery for colorectal cancer at the study centre.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the First Affiliated Hospital of Chongqing Medical University | Chongqing | Chongqing Municipality | 400016 | China |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| colorectal neoplasm | Diagnostic Test | Patients diagnosed with colorectal adenoma confirmed by colonoscopy. |
|
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D009750 | Nutritional and Metabolic Diseases |