The aim of this study is to investigate the effects of environmental factors, such as air pollution, on the occurrence, development and prognosis of colorectal cancer; to identify metabolic markers specific to colorectal cancer patients, which will provide a basis for early diagnosis, early intervention and individualized treatment; and to comprehensively understand the mechanism of the occurrence and development of colorectal cancer by integrating the data of environmental factors and the macro-genome, and to develop new predictive and therapeutic strategies.

Inclusion Criteria:

• Age ≥18 years old;
• Patients diagnosed with colorectal cancer by pathologic biopsy before surgery;
• Patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
• Willing to participate in the study and sign an informed consent form. Complete clinical data.

Exclusion Criteria:

• Concurrent primary malignant tumor other than colorectal cancer;
• Patients with severe cardiopulmonary insufficiency or other systemic diseases that affect the choice of treatment plan;
• Inappropriate for enrollment as assessed by the investigator;
• Incomplete clinical data.

Patients diagnosed with colorectal cancer by pathological biopsy and healthy participants with no history of malignancy were included in the study.

Data sharing is not permitted by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University.