Impact of Pre- and Post-operative Serum Metabolome Dynamics in Colorectal Resection Outcomes

Preoperative and Postoperative Changes in Serum Metabolome Dynamics in Colorectal Cancer Patients and Their Impact on Perioperative Clinical Outcomes

The aim of this study is to systematically analyze the dynamic pattern of preoperative and postoperative serum metabolites in colorectal cancer patients through metabolomics technology, and to screen the key metabolites with statistical differences and explore their correlation with surgical interventions by combining the baseline characteristics of the patients with the perioperative clinical data; to further reveal the impact of surgery on the body's metabolic remodeling pattern, and to explore the potential biomarkers and regulatory pathways, providing a theoretical basis for elucidating the metabolic mechanism. Investigaters will further reveal the impact of surgery on metabolic remodeling, explore potential biomarkers and regulatory pathways, provide theoretical basis for elucidating the metabolic mechanism, and evaluate its clinical translational value (e.g., postoperative monitoring, targeted intervention, etc.), so as to lay the foundation for the subsequent basic research and precise treatment strategies.

Inclusion Criteria:

• Previous consent to participate;
• Blood drawn and serum samples extracted and preserved both preoperatively and postoperatively;
• Successful detection of metabolomics profiles from serum samples;
• Acceptance of a standard radical colorectal cancer procedure;
• Complete perioperative data available;
• Adults with a pathologic diagnosis of colorectal cancer

Exclusion Criteria:

• Have or have had a previous history of other malignancies;
• Have a history of radiotherapy treatment;
• Have a history of inflammatory bowel disease;
• Have a familial history of genetic disorders;
• Missing baseline data (age, BMI, gender, previous medical history, etc.);
• Failed to leave the hospital earlier than medically indicated;
• Failed to sign an informed consent form.