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Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.
The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PLACEBO | Placebo Comparator | Energy matched placebo containing medium-chain triglycerides and bitter taste |
|
| KETONE | Experimental | Beta-hydroxybutyrate monoester |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketone ester | Dietary Supplement | 0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose concentrations | Blood glucose concentrations during the recovery period (240 minutes) | 240 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Non-oxidative fate of ingested sucrose | Non-oxidative fate of ingested glucose measured by appearance of 13C on breath CO2 from high 13C sucrose ingested during recovery | 240 minutes |
| Exercise capacity |
| Measure | Description | Time Frame |
|---|---|---|
| Blood beta-hydroxybutyrate concentrations | Blood beta-hydroxybutyrate concentrations throughout the 240 minute recovery | 240 minutes |
| Urinary urea | Urea in urine, determined by urea concentration multiplied by total urine output during the 240 minutes of recovery |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bath | Bath | Bath | BA2 7AY | United Kingdom |
Plan is to share individual deidentied data on a public repository such as Mendeleydata.
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| C524675 | formic acid 4-(3-oxobutyl)phenyl ester |
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| Placebo | Dietary Supplement | Medium chain triglycerides and bitter tastant (Bitrex) |
|
Time to exhaustion running at 70% of maximal aerobic capacity after the recovery period
| 240 minutes |
| 240 minutes |
| Blood lactate concentrations | Blood lactate concentrations during 240 minutes of recovery | 240 minutes |
| Plasma insulin concentrations | Plasma insulin concentrations during 240 minutes of recovery | 240 minutes |
| Blood pH | Blood pH during 240 minutes of recovery | 240 minutes |
| Blood bicarbonate | Blood bicarbonate concentrations during 240 minutes of recovery | 240 minutes |