Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 22231471 | Other Grant/Funding Number | Health and Medical Research Fund |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| The University of Hong Kong | OTHER |
| University of Reading | OTHER |
| Johns Hopkins University | OTHER |
Not provided
Not provided
Not provided
The proposed study aims to investigate the potential of IVR-CST in improving cognition of people with MCI, and as well the association of eye movement during therapy and treatment outcomes of IVR-CST. Four research questions have been proposed and listed as follows:
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IVR-CST Group | Experimental |
| |
| Conventional CST Group | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IVR-CST (Immersive Virtual Reality Cognitive Stimulation Therapy) | Behavioral | IVR-CST involves 14 sessions of cognitive stimulation therapy conducted twice a week in a virtual reality environment. Each session lasts approximately 45 minutes and utilizes head-mounted displays (HMDs) to immerse participants in engaging, themed activities. The therapy aims to enhance cognitive function and social interaction through interactive and stimulating virtual experiences tailored for individuals with mild cognitive impairment (MCI). |
| Measure | Description | Time Frame |
|---|---|---|
| Hong Kong Montreal Cognitive Assessment (HK-MoCA) | Hong Kong Montreal Cognitive Assessment (HK-MoCA) Measurement of global cognition in participants, covering various cognitive domains such as visuo-spatial skills, executive functions, attention, memory, language, and orientation. The total score ranges from 1-30, with higher score indicating better performance. | From 1-week pre-intervention to 13 weeks post-intervention |
| Digit Span Forward and Backward Tasks | Assessment of working memory capacity, predicting progression from MCI to dementia. The test will start from 1 digit with increasing number of digit to increase level of difficulty. | From 1-week pre-intervention to 13 weeks post-intervention |
| Verbal Fluency of Semantic Category | Evaluation of semantic integrity, cognitive flexibility, and executive function by measuring the number of items correctly produced in one minute across different semantic categories (animals, fruits, transportation). | From 1-week pre-intervention to 13 weeks post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Chinese Version of the Modified Barthel Index | Assessment of the level of independence in activities of daily living, including grooming, feeding, mobility, toileting, and more. The test score ranges from 1-100 with higher scores indicating better performance. | From 1-week pre-intervention to 13 weeks post-intervention |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Winsy WS Wong, PHD | Contact | 852-34003117 | wszewong@polyu.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Winsy WS Wong, PHD | The Hong Kong Polytechnic University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hong Kong Polytechnic University | Hong Kong | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40857307 | Derived | Wong WWS, Wong GHY, Choy JCP, Pui Li DS, Lo YL. Utilization of Immersive Virtual Reality in Cognitive Stimulation Therapy (IVR-CST) for elderly with mild cognitive impairment: A randomized controlled pilot study protocol. PLoS One. 2025 Aug 26;20(8):e0330686. doi: 10.1371/journal.pone.0330686. eCollection 2025. |
Not provided
Not provided
The IPD, together with the study protocol, will be shared in an open-access data repository (e.g., OSF).
Data will be shared starting from three months after manuscript publication.
The IPD and study protocol will be shared in an open-access data repository without restrictions.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Intervention Name: Conventional CST (Cognitive Stimulation Therapy) | Behavioral | Conventional CST consists of 14 sessions of cognitive stimulation therapy conducted twice a week, each lasting about 45 minutes. In this arm, participants engage in group activities using physical materials, such as photos, pictures, and real objects, rather than virtual reality. The therapy focuses on providing cognitive stimulation through discussions and activities designed to improve cognitive function and social engagement among individuals with mild cognitive impairment (MCI). |
|
| Hong Kong Lawton Instrumental Activities of Daily Living Scale |
Evaluation of independence in performing community-living skills, such as cooking, household management, and shopping. The test score ranged from 0-18 and a higher score indicates better performance. |
| From 1-week pre-intervention to 13 weeks post-intervention |
| Feasibility Outcomes and Users' Experience | Objective measures of feasibility, including the number of adverse events and technical issues during the intervention, as well as adherence to the intervention protocol (actual duration and number of sessions conducted vs. scheduled). | Throughout the intervention period (from weeks 1-7 of intervention) |
| Semi-Structured Interview for IVR-CST Group | Post-therapy interview assessing comfort levels, presence of adverse effects (e.g., cybersickness), and the impact of therapy on daily functions. Conducted by a trained research assistant in a quiet clinical room, with the session audio-taped. | Immediately post-intervention |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided