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This is a randomized, open-label study comparing intial settings made by clinicians with settings recommandation made by the VentilO application immediately after intensive care unit admission.The study will allow direct comparison of the frequency of acidosis when patients are ventilated using the parameters of the VentilO application versus parameters chosen by the clinician. The variables determined by the clinician or VentilO will be respiratory rate, tidal volume and resulting minute ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Clinicians | Other | Clinicians include respiratory therapists, physcians, medical students |
|
| VentilO | Active Comparator | VentilO, smartphone application (or web plateform) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinicians | Other | Clinicians will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory acidosis | The frequency of respiratory acidosis on arterial gas after 20 minutes of mechanical ventilation (pH < 7.35 and PaCO2 > 45mmHg) | 20 minutes after initiation of mechanical ventilation |
| Measure | Description | Time Frame |
|---|---|---|
| Acid-base disorders on arrival in intensive care | The frequency and severity of acid-base disorders on arrival in intensive care (pH<7.35 or pH > 7.45) | 5 minutes after initiation of mechanical ventilation |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with hemodynamic shock - hypotension | Requiring >1L of volume repletion and/or use of amines at >0.05 mcg/kg/min or norepinephrine equivalent | Up to extubation |
| Number of participants with a barotrauma |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francois Lellouche Principal investigator, MD, PhD | Contact | 1-418-656-8711 | 3572 | francois.lellouche@criucpq.ulaval.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval | Recruiting | Québec | Quebec | G1V4G5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41711585 | Derived | Roch R, Bouchard PA, Couture E, Lellouche F. Patient-Centered Ventilator Settings to Reduce Respiratory Acidosis After Cardiac Surgery. Respir Care. 2026 Apr;71(4):366-374. doi: 10.1177/19433654251412340. Epub 2026 Feb 19. |
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| ID | Term |
|---|---|
| D000142 | Acidosis, Respiratory |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D000138 | Acidosis |
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| ID | Term |
|---|---|
| D009720 | Nurse Clinicians |
| ID | Term |
|---|---|
| D000072184 | Nurse Specialists |
| D009726 | Nurses |
| D006282 | Health Personnel |
| D005159 | Health Care Facilities Workforce and Services |
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| VenitlO | Device | VentilO application (or web platerform) will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit. |
|
Presence of pneumothorax
| Up to extubation |
| Mortality | Intensive care unit mortality | Up to intensive care unit discharge |
| Intensive care unit lenght of stay | Intensive care unit lenght of stay | Up to 28 days - intensive care unit length of stay - intensive care admission to intensive care discharge |
| Number of participants with an acute kidney injury | Acute kidney injury define by > 27 mmol for 48 hours or 1.5 x basline value (pre surgery) | Up to 28 days - intensive care unit length of stay - intensive care admission to intensive care discharge |
| D000137 |
| Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |