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Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock. Optimization of settings during mechanical ventilation and implementation of protective ventilation help to avoid ventilation-induced injury, ensure adequate oxygenation and maintain adequate carbon dioxide concentration to avoid respiratory acidosis or alkalosis.
Similarly, there is also no clear recommendation, to our knowledge, for the initial setting of the respiratory rate. Therefore, initial settings are not always adequate and in the literature the frequency of respiratory acidosis is very high, reaching about half of the patients receiving mechanical ventilation.
VentilO, is an application that is available on smart phones. This educational application provides clinicians with initial settings and optimization of these settings based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations and the anatomical and instrumental dead space of patients.
The purpose of our study is to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intubated patient during their stay in the IUCPQ-UL emergency or intensive care department |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VentilO application | Other | This educational application provides clinicians with combinations of tidal volume and respiratory rate based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations (i.e. from intubated patients for scheduled surgery to the most severe ICU patients) and anatomical and instrumental dead space. The objective of this application is to help implement personalized protective ventilation in intubated patients according to their characteristics. After patient data entry in the VentilO appllication we will compare the recommended settings (for mechanical ventilation) vs the real clinicial settings done by clinician after patient intubation.We will evaluated the potential effect of the VentilO recommendation on the first arterial (or capillary) blood gases compared to the real settings. |
| Measure | Description | Time Frame |
|---|---|---|
| acid-base abnormalities on arterial (or capillary) blood gases | evaluate the frequency of acid-base abnormalities, either acidosis or alkalosis, of respiratory or mixed origin on the first arterial gases after intubation. Respiratory acidosis is defined as a pH < 7.35 with a PaCO2 > 45 mmHg, and respiratory alkalosis as a pH > 7.45 with a PaCO2 < 35 mmHg) | on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation |
| Improvement acid-base abnormalities with the VentilO application |
| on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation |
| Impairement acid-base abnormalities with the VentilO application |
| on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of optimal arterial (or capillary) blood gases result | An optimal arterial (or capillary) blood gases as defined by a pH between 7.35 and 7.45 with a PaCO2 between 36 and 45 mmHg | on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation |
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Inclusion Criteria:
Exclusion Criteria:
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Intubated patients during their stay in the IUCPQ-UL emergency or intensive care department
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Universitaire de Cardiologie et de Pneumologie de Québec | Québec | Quebec | G1V4G5 | Canada |
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| Severity of unbalance of arterial (or capillary) blood gases result |
For acid-base abnormalities, they will be evaluated according to their level of severity: the frequency of moderate (pH between 7.30 and 7.34) and severe (pH < 7.30) acidoses, and the frequency of moderate (pH between 7.46 and 7.50) and severe (pH > 7.50) alkaloses. The frequency of moderate (PaCO2 between 46 and 50 mmHg) and severe (PaCO2 > 50 mmHg) hypercapnia, and the frequency of moderate (PaCO2 between 31 and 35 mmHg) and severe (PaCO2 < 31 mmHg) hypocapnia |
| on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation |
| hemodynamic instabilities | arterial hypotension requiring vascular filling > 1000 ml and/or use of vasopressors or inotropes such as levophed or adrenaline at > 0.05 mcg/kg/min) | Between Hour0 to Hour1 after intubation |
| ICU length of stay | ICU length of stay - ICU admission through ICU discharge | up to 90 days. ICU stay - ICU admission through ICU discharge or until death if occured |
| Hospital length of stay | Hospital length of stay - Emergency department admission through hospital discharge | up to 90 days. ICU stay - Emergency department admission through hospital discharge or until death if occured |
| ICU mortality | Occurence of death during ICU stay | up to 90 days. ICU admission through until death if occured |