Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.
The aim of the study is to:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Thoracic surgery | Patient managed with one lung ventilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| one lung ventilation | Other | Arterial blood gases during one lung ventilation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory acidosis | The frequency of respiratory acidosis on arterial blood gases after 20 minutes of mechanical ventilation (pH < 7.35 and PaCO2 > 45mmHg) measured by arterial blood gases | 20 minutes after initiation of one lung ventilation after lung isolation |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory rate | Respiratory rate set by the doctor, this respiratory rate will be compared to the suggestion of the algorithm | At the beginning of one lung ventilation during the surgery |
| Acid-base disorder |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Patient undergoing thoracic surgery requiring intraoperative one-lung ventilation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francois Lellouche | Contact | 1-418-656-8711 | francois.lellouche@criucpq.ulaval.ca |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval | Recruiting | Québec | Quebec | G1V4G5 | Canada |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Presence of Respiratory alkalosis define by pH>7.45 and PaCO2 < 35 mmHg
| At the beginning of one lung ventilation during the surgery |
| Number of participants with hemodynamic shock - hypotension | Requiring >1L of volume repletion and/or use of amines at >0.05 mcg/kg/min or norepinephrine equivalent | Day 1 |
| Hospital length of stay | Recovery room admission through hospital discharge | Up to 90 days |
| Mechanical Ventilation duration | Time spent with invasive mechanical ventilation during surgery and hospital stay | Up to 90 days |
| Hospital mortality | Occurence of death during hospital stay | Up to 90 days |
| ID | Term |
|---|---|
| D006935 | Hypercapnia |
| D000138 | Acidosis |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D061810 | One-Lung Ventilation |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
Not provided
Not provided