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| ID | Type | Description | Link |
|---|---|---|---|
| 341708 | Registry Identifier | The Integrated Research Application System (IRAS) in UK |
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The study will look at whether online mindfulness meditation (OMM) is easy for older adults with mild cognitive impairment (MCI) and mild dementia to use. It will also see how OMM affects their mood, sleep, and quality of life.
The investigators will recruit 32 participants, divided into 4 groups of 8 people each.
Participants will:
This research aims to investigate the feasibility and acceptability of online meditation for older adults with mild cognitive impairment (MCI) and mild dementia in the UK and to explore its impact on cognitive function, mood, mindfulness, and quality of life. This study will recruit 32 participants with MCI and mild dementia. Participants will receive mindfulness meditation training in an online group-based format, with 8 participants per group in 4 waves. A qualified meditation teacher will lead the sessions via Microsoft Teams once a week for 8 weeks (lasting 2 to 2.5 hours per session).
The study outcomes will include feasibility of the intervention, acceptability to participants, cognitive function, mindfulness, and quality of life. Data will be collected at baseline and after the intervention. A paired t-test will compare pre- and post-intervention changes if the data meet assumptions of normal distribution and homogeneity of variance. Otherwise, non-parametric statistical analyses will be applied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Online mindfulness meditation arm | Experimental | Participants over 60 years old with mild cognitive impairment or mild dementia will be recruited. An 8-week online meditation training program will be provided. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Online mindfulness meditation | Behavioral | The mindfulness meditation program is adapted from the Breathwork Mindfulness for Stress program. However, it uses shorter meditations designed for individuals who cannot sit for 40 minutes. The mindfulness meditation program encourages greater self-acceptance, kindness, and compassion toward oneself. It builds on this concept by helping participants find pleasure in life despite suffering, fostering kindness and compassion toward others, and increasing social connections to counteract the social isolation common among individuals with chronic and long-term illnesses. The program will be led by a well-trained Breathwork mindfulness instructor and conducted remotely via Microsoft Teams once a week for 8 weeks. Each session will last 2 to 2.5 hours and consist of body scans, mindful movements, and various meditations, introducing new ideas every week. |
| Measure | Description | Time Frame |
|---|---|---|
| Conversion rate | Conversion Rate= Number of participants enrolled / Number of potential participants contacted × 100% | through study completion, an average of 1 year |
| Retention rate | Retention Rate (%)= Number of participants who completed the study / Number of participants initially enrolled × 100% | through study completion, an average of 1 year |
| Attrition rate | Attrition Rate (%)= Number of participants who dropped out / Total number of participants initially enrolled × 100% | through study completion, an average of 1 year |
| Client Satisfaction Questionnaire | It is a standardized 8-item tool that has demonstrated good reliability and validity in mental health services. Items are scored from 1 (low satisfaction) to 4 (high satisfaction) with different descriptors for each response point. Total scores range from 8 to 32, with higher scores indicating greater satisfaction. | immediately after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Modified Telephone Interview for Cognitive Status | The Modified Telephone Interview for Cognitive Status is a brief, 13-item test of cognitive functioning with total scores ranging from 0 to 50. Questions of orientation, repetition, naming, and calculations are some of the items covered. Additionally, a 10-item non-semantically related word list is recalled both immediately and after a delay of about 5 minutes filled with distractor questions. Higher scores mean a better outcome. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jiuhong You | Contact | +447562739403 | jiuhong.you@kcl.ac.uk | |
| Zunera Khan | Contact | zunera.2.khan@kcl.ac.uk |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41289241 | Derived | You J, Khan Z, Swaroop R, Sun Y, Velayudhan L, Aarsland D. Online mindfulness meditation for mild cognitive impairment and mild dementia: A feasibility study protocol. PLoS One. 2025 Nov 25;20(11):e0336583. doi: 10.1371/journal.pone.0336583. eCollection 2025. |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
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|
| baseline and immediately after the intervention |
| Pittsburgh sleep quality index | It is a self-rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval. Nineteen individual items generate seven component scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The total scores range from 0 to 21. Higher scores mean a worse outcome. | baseline and immediately after the intervention |
| Hospital anxiety and depression scale | It is used in the setting of a general medical hospital outpatient clinic to assess the mental health of patients. It has two subscales (anxiety and depression), each with seven items and a score of 0-3 for each item, the total score is 21 respectively. Higher scores indicate a worse condition. | baseline and immediately after the intervention |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |