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The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are:
Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group).
Participants will:
Outcomes will be assess at baseline, 2 months, 4 months and 6 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mindfulness | Experimental | MBSR course of mindfulness using focused attention, body scan practice and light chair yoga. |
|
| Mindfulness Waitlist | No Intervention | Individuals in the Mindfulness Waitlist group will not engage in any of the study interventions until 2 months has passed. Then they will be enrolled in the Mindfulness Intervention. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mindfulness Intervention | Behavioral | The Mindfulness Intervention is an adapted form of Mindfulness-based stress reduction (MBSR) training virtual class that meets for 10 weeks. The class involves mindfulness training using awareness and focused attention, group discussion of the experience, and mindful movement. The Mindfulness Intervention also includes daily home practice using mindfulness recordings. |
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychological tests | Paper-and-pencil tests measuring attention, processing speed, and memory. | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks) |
| Performance on computerized tasks | Reaction time and accuracy on computer tasks measuring attention and memory | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks) |
| Resting state and event-related electrophysiology | Electrophysiology measured while at rest and time-locked to performance on a computerized task measuring attention and memory | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks) |
| Brain function and structure | Blood-oxygen-level-dependent (BOLD) for functional magnetic resonance imaging. Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) for structural magnetic resonance imaging. | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)) |
| Survey outcomes | Surveys measuring mood, social isolation, sleep, and quality of life | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Katherine W Turk, MD | Contact | 8573645429 | ctcnbrainlab@gmail.com | |
| Kathy Y Xie, PhD | Contact | 8572300905 | ctcnbrainlab@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Boston Healthcare System - Jamaica Plain Campus | Recruiting | Boston | Massachusetts | 02130 | United States |
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|
|
| Waitlist then mindfulness | Behavioral | Participants in this arm will first wait 10 weeks and then complete a mindfulness course with outcome measures assessed at baseline, after 10 weeks wait list and then after mindfulness course. |
|
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D000070642 | Brain Injuries, Traumatic |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D003704 | Dementia |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
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| ID | Term |
|---|---|
| D000099024 | Mindfulness-Based Stress Reduction |
| D019122 | Meditation |
| ID | Term |
|---|---|
| D064866 | Mindfulness |
| D015928 | Cognitive Behavioral Therapy |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026443 | Spiritual Therapies |
| D012064 | Relaxation Therapy |
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