Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in COPD patients.
The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. These comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. Addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of COPD. According to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. Blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to COPD rehabilitation.
The research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with COPD. The findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of COPD.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual care group | Active Comparator | The Usual care group will receive COPD and exercise-related education. |
|
| Aerobic exercise group-cycling | Experimental | The aerobic exercise group will receive cycling training intervention 2-3 times per week for 2 months. |
|
| BFR group-cycling + BFR | Experimental | The BFR group will receive cycling training combined with BFR intervention 2-3 times per week for 2 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic exercise intervention | Behavioral | The aerobic exercise intervention will utilize an ergometer. The program will be conducted 2-3 times per week over a 3-month period. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen consumption (VO2) | Oxygen consumption examined by cardiopulmonary exercise test | Change from baseline (0 week) to follow up (20 weeks) |
| Diaphragm capacity | Diaphragm capacity examined by diaphragmatic ultrasound | Change from baseline (0 week) to follow up (20 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Functional capacity | Functional capacity examined by 6MWT | Change from baseline (0 week) to follow up (20 weeks) |
| Heart Rate Variability | Heart Rate Variability examined by autonomic nervous system |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kun-Ling Tsai, Ph.D. | Contact | 886-6-2353535 | 5078 | kunlingtsai@mail.ncku.edu.tw |
| Yu-Ting Huang, M.S. | Contact | 886-6-2353535 | 5078 | t66061053@pt.ncku.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Kun-Ling Tsai, Ph.D. | Department of Physical Therapy, National Cheng Kung University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Cheng Kung University Hostipal | Recruiting | Tainan | Taiwan | 701 | Taiwan |
IPD sharing plan will be decided after summarized data being published.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
Not provided
Not provided
| ID | Term |
|---|---|
| D008722 | Methods |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Disease and exercise suggestion | Behavioral | The participants will be provided by educational program about COPD self-care and home-based exercise approach. |
|
| Blood flow restriction (BFR) intervention | Behavioral | Blood flow restriction (BFR) intervention will combine aerobic exercise on the ergometer with BFR training. The program will be conducted 2-3 times per week over a 3-month period. |
|
| Change from baseline (0 week) to follow up (20 weeks) |
| Pulmonary function test | Pulmonary function test examined by spirometer. Spirometry is a physiological test that measures the ability to inhale and exhale air over time. The main spirometry results are forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the FEV1/FVC ratio. | Change from baseline (0 week) to follow up (20 weeks) |
| Maximum respiratory pressure | Maximum respiratory pressure examined by pressure meter | Change from baseline (0 week) to follow up (20 weeks) |
| Quality of life score (COPD-related questionnaire-I) | Quality of life score examined by mMRC Questionnaire. | Change from baseline (0 week) to follow up (20 weeks) |
| Quality of life score (COPD-related questionnaire-II) | COPD Assessment Test (CAT) questionaire | Change from baseline (0 week) to follow up (20 weeks) |
| Quality of life score (COPD-related questionnaire-III) | St George's Respiratory Questionnaire (SGRQ) | Change from baseline (0 week) to follow up (20 weeks) |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |