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The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BFR-ST and BFR-HIT | Experimental | Participants will be allocated to a BFR intervention including resistance training and high-intensity intervals performed on a bicycle ergometer, both performed with BFR. |
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| HL-ST and HIT | Active Comparator | Participants will be allocated to heavy load resistance training and high-intensity intervals performed on a bicycle ergometer, both performed without BFR |
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| BFR-P | Experimental | Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR. |
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| BFR-NMES | Experimental | Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR with neuromuscular electrical stimulation (BFR-NMES) twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR-NMES. |
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| Control group | Active Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BFR during training | Other | Healthy participants and participants diagnosed with COPD will be randomized to either the BFR-ST and BFR-HIT or to HL-ST and HIT |
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| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength | Maximal voluntary isometric contraction of m. quadriceps femoris | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) |
| Measure | Description | Time Frame |
|---|---|---|
| Lean mass | Lean mass assessed by dual X-ray absorptiometry (DXA) | Change assessed from before to after the 6 week intervention |
| Maximal oxygen consumption | VO2max during incremental exercise |
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Inclusion criteria for participants with COPD group are:
Exclusion criteria participants in the COPD group are
Inclusion criteria for healthy participants are:
Exclusion criteria for healthy participants are:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Morten Hostrup | Contact | +4535321595 | mhostrup@nexs.ku.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| August Krogh Building | Recruiting | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will allocated to usual care, consisting of daily physiotherapy sessions. |
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| BFR during rest | Other | Participants experiencing acute exacerbation of their COPD requiring hospitalization will be randomized to either BFR-P, BFR-NMES or the control group throughout their hospitalization. |
|
| Change assessed from before to after the 6 week intervention |
| Skeletal muscle mitochondrial respiration | High resolution respirometry | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) |
| Fiber cross-sectional area | Immunohistochemistry to determine fiber cross-sectional area | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) |
| Myonuclei | Immunohistochemistry to determine number of myonuclei | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) |
| Functional exercise capacity | Number of repetitions achieved during a 1-minute sit-to-stand test | Change assessed from before to after the 6 week intervention (only in individuals with COPD) |
| Satellite cells | Immunohistochemistry to determine number of satellite cells | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |