Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy

Combination of Dexmedetomidine Nasal Spray and Remimazolam for the Treatment of Pediatric Bronchoscopy

To observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy diagnosis and treatment

Dexmedetorimidine nasal spray is a new dosage form, which is simple and easy to achieve sedative and anti-anxiety effects by nasal spray mucosa. In the dose range from 50 to 100 μ g, the sedation effect increased dose-dependent, with> 2 μ g / kg administered, and the child could be successfully separated within 45min.Our study is to observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy diagnosis and treatment

Inclusion Criteria:

• Age 2-6 years old (24~72 months);
• ASA I-II;
• sign the informed consent.

Exclusion Criteria:

• Severe rhinitis, nasal deformity;
• abnormal liver and kidney function;
• severe dehydration, severe malnutrition, hypoproteinemia or anaemia Hb <10 g/dl;
• children with neurological disease;
• history of allergy to the study drug;
• recent participation in other clinical studies.