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The study will evaluate clinical outcomes during bronchoscopy procedures with dexmedetomidine in comparison to propofol.
The clinical outcomes that will be evaluated are: oxygen saturation, transcutaneous Pco2, blood pressure and complications
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine | Active Comparator | Dexmedetomidine will be used for sedation during bronchoscopy |
|
| Propofol | Placebo Comparator | Propofol will be used for sedation during bronchoscopy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Dexmedetomidine will be used for sedation during bronchoscopy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| number of de-saturation events | Number of events during bronchoscopy when saturation level decreased under 90% | During the procedure |
| Oxygen saturation time < 90% | Total time during the procedure that the oxygen saturation was under 90% | During the procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Barak Pertzov, MD | Contact | 972548080196 | pertzovb@gmail.com | |
| Mordechai Kramer, MD | Contact | 97239377224 | Kremerm@clalit.org.il |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rabin Medical Center | Recruiting | Petah Tikva | 49100 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35291989 | Derived | Pertzov B, Krasulya B, Azem K, Shostak Y, Izhakian S, Rosengarten D, Kharchenko S, Kramer MR. Dexmedetomidine versus propofol sedation in flexible bronchoscopy: a randomized controlled trial. BMC Pulm Med. 2022 Mar 15;22(1):87. doi: 10.1186/s12890-022-01880-9. |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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Randomised controlled trial
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| Propofol |
| Drug |
Propofol |
|
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |