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The purpose of this project is to explore the relationship between the effect of coffee on exercise performance and caffeine metabolism.
The investigators will study the relationship between the impact of coffee on exercise and caffeine metabolism. The investigators will recruit healthy elite athletes. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. Each participant does six rides, with one day of caffeine washout before each ride. In all trials, each participant will ride at the same time of day. Before riding, drink 200 ml water, decaffeinated coffee or coffee in random order, and the caffeine content of coffee is 200 mg. After 60 minutes of drinking, they start riding, after the completion of the riding, the subjects perceived and judged the perception between the baseline load and the comparison load. After the completion of the judgment, the next level of stimulus parameters will randomly generated to conduct the experiment. Each person conducted 6 groups of intervention experiments. Changes in average exercise performance, heart rate, electrocardiogram and body temperature will be observed after drinking decaffeinated coffee or coffee compared with drinking water. The concentration of caffeine and its metabolites in urine before and after drinking within 3 hours will be measured by liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Water | Placebo Comparator | The participants will drink 200 ml water. |
|
| Decaffeinated coffee | Experimental | The participants will drink 200 ml decaffeinated coffee. |
|
| Coffee | Experimental | The participants will drink 200 ml coffee, the caffeine content is 200 mg. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Caffeine content | Other | Participants will drink the same volume of water or coffee with different amounts of caffeine. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Exercise performance | After the completion of the riding, the subjects perceived and judged the perception between the baseline load and the comparison load. | On the experimental day, it lasts 2 weeks. |
| Urine metabolites | The contents of metabolites will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ). | On the experimental day, it lasts 2 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Body temperature | Body temperature of participants will be measured by ear temperature gun. | On the experimental day, it lasts 2 weeks. |
| Electrocardiogram (ECG) | ECG of participants will be measured by Amu ECG belt, the changes in P wave, PR interval, PR segment, QRS wave group, J point, ST segment, T wave, QT interval, and U wave will be observe. |
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Inclusion Criteria:
Healthy adults 18-40 years old
Exclusion Criteria:
Diabetes Hypoglycemia Gout Osteoporosis Gastric ulcer Pancreatitis Intestinal obstruction Blood phobia Pathological hypo or hyper tension Impaired glucose tolerance Claustrophobia HIV,etc.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| John R Speakman, PhD | Contact | 15810868669 | j.speakman@abdn.ac.uk | |
| Huanan Zhang, Master | Contact | 13371016641 | hnzhang2021@163.com |
| Name | Affiliation | Role |
|---|---|---|
| John R Speakman, PhD | Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences | Recruiting | Shenzhen | Guangdong | 518055 | China |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| On the experimental day, it lasts 2 weeks. |
| Blood pressure | Systolic and diastolic blood pressure of participants will be measured by Omron digital sphygmomanometer. | On the experimental day, it lasts 2 weeks. |
| Height | Height will be measured by seca 217 stable stadiometer. Subjects wearing no shoes. | The morning of the first day of the experiment, 5 mins |
| Body weight | Fasting body weight will be measured by Bioimpedance Analysis (TANITA, MC-980). | The morning of the first day of the experiment, 5 mins |
| Fat mass | Fat mass will be measured by Magnetic Resonance Imaging (Shanghai united imaging, uMR 790 ). | The morning of the first day of the experiment, 10 mins |
| Fat free mass | Fat free mass will be measured by Bioimpedance Analysis (Tanita, MC-980). | The morning of the first day of the experiment, 10 mins |
| Bone mass | Bone mass will be measured by Dual Energy X-ray Absorptiometry (Horizon Wi). | The morning of the first day of the experiment, 10 mins |
| Heart rate | Heart rate will be measured by heart rate belt. | 2 weeks |
| Waist circumferences | Waist circumferences will be measured using a whole body laser scanner (TG2000-F). | The morning of the first day of the experiment,10 mins |