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Evaluation of the application effect of compound chlorhexidine gargle in oral care of patients with endotracheal intubation based on 16s RNA technology.
Evaluation of the application effect of compound chlorhexidine gargle in oral care of patients with endotracheal intubation based on 16s RNA technology. Between September 2022 and March 2023, 68 patients admitted to the ICU for endotracheal intubation were collected. They were randomly divided into intervention group and control group, with 34 cases in each group. The control group used the method of wiping, washing and saline (0.9%) three times a day, and the intervention group was using the method of wiping, washing and 0.12% chlorhexidine gluconate three times a day.The results were analyzed at three time points before the first oral care after intubation, before oral care 48 hours after intubation, and before oral care on the 5th day after intubation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Saline Group | Other | oral wiping and oral care solution rinsing, oral care solution was 0.9% normal saline, and oral care frequency was 3 times a day. |
|
| Chlorhexidine group | Experimental | oral wiping and oral care solution rinsing, oral care solution was 0.12% Chlorhexidine gluconate solution, and oral care frequency was 3 times a day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chlorhexidine Gluconate | Drug | oral wiping and oral care solution rinsing, oral care solution was 0.12% chlorhexidine gluconate, and the frequency of oral care was 3 times a day. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in the oral microbiota | objective analysis results based on 16s RNA technology | Immediately after enrollment; 48 hrs after intubation；5 days after intubation |
| Measure | Description | Time Frame |
|---|---|---|
| oral complications | Oral complication occurrences: The occurrences of oral mucosa bleeding, oral inflammation, oral ulcers, fungal and herpes virus infections, tongue falling backwards, laryngeal edema, granulomas, and other complications were recorded in elderly patients undergoing mechanical ventilation at 0 hours, 2 days, and 5 days post-intervention. Diagnosis was confirmed through blood routine tests, histopathological examinations, smear tests, fungal cultures, or other methods. |
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Inclusion Criteria:
Exclusion Criteria:
Exclusion During Study:
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| Name | Affiliation | Role |
|---|---|---|
| sheng wang, PHD | Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changcui Qiu | Shanghai | 200072 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41456054 | Derived | Qiu C, Tang L, Hang Z, Wei K, Wang S, Zhu X, Wang Q. Effect of chlorhexidine vs. saline for oral care on oral microbiota and prognosis of elderly mechanically ventilated patients in the intensive care unit: a single-center, single-blind, randomized controlled trial. BMC Oral Health. 2025 Dec 28;26(1):199. doi: 10.1186/s12903-025-07579-7. |
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| ID | Term |
|---|---|
| C010882 | chlorhexidine gluconate |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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|
| normal saline | Other | oral wiping and oral care solution rinsing, oral care solution was 0.9% normal saline, and the frequency of oral care was 3 times a day. |
|
| mechanical ventilation at 0 hours, 2 days, and 5 days post-intervention |
| plaque Index | Dental Plaque Index: The mesial buccal, middle buccal, distal buccal, and lingual surfaces of the teeth in elderly patients undergoing mechanical ventilation were examined and scored using a combination of visual inspection and probing. A score of 0 indicates no plaque at the gingival margin, 1 indicates a thin layer of plaque at the gingival margin, 2 indicates moderate plaque at the gingival margin or interproximal area, and 3 indicates abundant soft debris within the gingival sulcus, at the gingival margin, and in the interproximal area. The Dental Plaque Index is calculated as the sum of the plaque scores for each tooth divided by the total number of teeth examined. | mechanical ventilation at 0 hours, 2 days, and 5 days post-intervention |
| whether VAP occurs | the recorder records whether VAP occurs after endotracheal intubation;Ventilator-associated pneumonia (VAP) refers to pneumonia that occurs between 48 hours after the initiation of mechanical ventilation (MV) and 48 hours after extubation. It is an important type of hospital-acquired pneumonia (HAP). Among them, pneumonia that occurs within 4 days of MV is classified as early-onset VAP, while that occurring on or after the 5th day is classified as late-onset VAP. | Immediately after enrollment; 48 hrs after intubation；5 days after intubation |
| 28-day mortality rate | Survival status at day 28 | 28 days post-randomization |