Ventilator-associated pneumonia and ventilator-associated treakeabronchitis in respiratory tract infections associated with ventilator are common infections in intensive care unit and cause significant morbidity, mortality and health expenditures in nosocomial infections. Adequate and effective oral care by nurses in intensive care patients, possible complications, intensive care unit stay in the intensive care unit and is very important in terms of mortality.

The aim of this study will (1) evaluate the effect of 0.12% chlorhexidine gluconate on ventilator-associated pneumonia, ventilator-associated treakeabronchitis, (2) determine the effect of preventing microorganism colonization, and (3) assess the mortality rate for each patient and the cost-effectiveness in the health expenditures.

Inclusion Criteria:

• Age ≥ 18 years
• Admission in critical care with in 24 hours
• Having an endotracheal tube

Exclusion Criteria:

• History of chlorhexidine allergy
• Duration of mechanichal ventilation less than 48 h
• Confirmed diagnosis of pneumonitis before admission in the ICU
• Transfer from another ICU
• Receiving chemotherapy or radiotherapy
• Patients with immunodeficiency
• Patients with tracheostomies
• Required specific oral hygiene procedures
• Facio-maxillary or dental trauma/surgery
• Being pregnant