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This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher mortality rates and longer hospitalization times. One group will receive the 0.12% chlorhexidine mouthwash and the other group will receive the 2% chlorhexidine mouthwash.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chlorhexidine 2% | Experimental | Subjects in this arm will receive standard care plus mouth rinse every 12 hours via spray with 2% chlorhexidine concentration, one week intervention, Drug: Chlorhexidine gluconate at 2% |
|
| Chlorhexidine 0.12% | Active Comparator | Subjects in this arm will receive standard care plus mouth rinse every 12 hours via spray with 0.12% chlorhexidine concentration, one week intervention, Drug: Chlorhexidine gluconate at 0.12% |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chlorhexidine gluconate at 2% | Drug | Mouth Rinse with Chlorhexidine gluconate at 2% every 12 hours, one week. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gram-negative decolonization rate | Patients admitted to the ICU who were originally colonized with gram-negative bacteria and at the end of the study are no longer colonized by gram-negative bacteria. | 2 weeks |
| Gram-negative colonization rate | Patients admitted to the ICU who were originally not colonized with gram-negative bacteria and at the end of the study are colonized by gram-negative bacteria. | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| José A Álvarez, PhD | Contact | 52 477 2674900 | 4643 | alvarez_ja@me.com |
| Marco A López, MD | Contact | 524641212911 | blackadam_@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Jose A Alvarez, PhD | Universidad de Guanajuato | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Guanajuato | Recruiting | León | Guanajuato | 37000 | Mexico |
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| Chlorhexidine gluconate at 0.12% | Drug | Mouth Rinse with Chlorhexidine gluconate at 0.12% every 12 hours, one week. |
|
| ID | Term |
|---|---|
| D053717 | Pneumonia, Ventilator-Associated |
| ID | Term |
|---|---|
| D000077299 | Healthcare-Associated Pneumonia |
| D003428 | Cross Infection |
| D007239 | Infections |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D007049 | Iatrogenic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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