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The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory.
Participants will undergo two visits with a memory task and nap. During one of the visits, quiet sounds will be played timed with sleep oscillations. During the other visit, no sounds will be played. Brain oscillations and memory will be measured at each visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Auditory Stimulation | Active Comparator | Quiet sounds are played during sleep |
|
| Sham Stimulation | Sham Comparator | Volume is set to zero. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quiet Sounds | Other | Quiet sounds are played during sleep |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep spindle rate | Sleep spindles are prominent thalamocortical brain oscillations seen on EEG during sleep that have been mechanistically linked to sleep-dependent memory consolidation. The sleep spindle rate over the course of the nap will be assessed using an automated spindle detector applied to the collected EEG sleep data. | 90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Memory consolidation | The motor sequence task (MST), a validated probe of memory consolidation, will be used to measure sleep-dependent memory consolidation. Participants will trained on MST before the nap opportunity and tested on MST after the nap opportunity to reliably measure memory consolidation. | 90 minutes |
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Inclusion Criteria: Adult -
Exclusion Criteria: History of neurological disease, psychiatric disease, sleep apnea or sleep disorder.
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| Name | Affiliation | Role |
|---|---|---|
| Catherine Chu, MD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Athinoula A. Martinos Center Biomedical Imaging | Charlestown | Massachusetts | 02129 | United States |
Deidentified data will be shared upon request to the study PI
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within one year of study termination
Academic investigators
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| Sham Sounds |
| Other |
No sounds are played during sleep |
|