Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Schizophrenia | Experimental | Adult outpatients with a diagnosis of schizophrenia. |
|
| Healthy Controls | Active Comparator | Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Closed loop auditory stimulation during sleep | Other | Short bursts of pink noise delivered at precise times during overnight sleep at home. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in sleep physiology | Changes in slow oscillations, sleep spindles, and slow oscillation-spindle coupled events as measured by sleep EEG headband | across 5 nights of sleep with auditory stimulation |
| Changes in functional connectivity of the hippocampus and thalamus | Changes in functional connectivity of the hippocampus and thalamus as measured by resting state functional connectivity MRI | Approximately 1 week between baseline and follow-up scans |
| Changes in hippocampal activation during motor sequence task (MST) | Changes in hippocampal activation during the MST as measured by functional MRI | Approximately 1 week between baseline and follow-up scans |
| Changes in hippocampal microstructural integrity | Changes in hippocampal microstructural integrity as measured by diffusion-weighted MRI | Approximately 30 minutes between pre- and post-task diffusion-weighted MRI scans |
| Measure | Description | Time Frame |
|---|---|---|
| Greater gains in typing speed over rest breaks during MST training (micro-offline gains) | MST training sessions prior to sleep consisting of typing trials separated by rest periods. We will measure typing speed before and after rest breaks. | Approximately 5 days between pre- and post-stimulation MST administrations |
Not provided
Inclusion Criteria:
Additional inclusion for Adults with schizophrenia:
Exclusion Criteria:
Additional Exclusion Criteria for Healthy adults:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lindsey Jones, MS | Contact | 617-702-2368 | manoachlab@gmail.com | |
| Dara Manoach, PhD | Contact | 617-724-6148 | dara.manoach@mgh.harvard.edu |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Recruiting | Charlestown | Massachusetts | 02129 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Sleep dependent memory consolidation (SDMC) |
Comparison of SDMC between the Baseline MST only and MST with CLASS nights |
| Approximately 5 days between pre- and post-stimulation MST administrations |