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The investigators will test the hypothesis that auditory stimulation (playing quiet sounds during sleep) can normalize brain activity during sleep and improve memory in patients with schizophrenia. The investigators will do this by measuring sleep and memory performance under two conditions separated by one week: receiving auditory stimulation during sleep and not receiving auditory stimulation during sleep. The investigators will study healthy subjects and outpatients with schizophrenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Schizophrenia | Experimental | Adult outpatients with a diagnosis of schizophrenia. |
|
| Healthy Controls | Experimental | Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Other | Auditory stimulation will not be delivered during the nap |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in slow-oscillation spindle coupling | Differences in slow oscillation-spindle coupling during non-rapid eye movement (NREM) sleep as measured by EEG between placebo and auditory stimulation naps | Placebo and auditory stimulation naps will be approximately one week apart |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in sleep-dependent consolidation of motor procedural memory | Differences in sleep-dependent improvement of motor procedural memory performance on the finger tapping motor sequence task (MST) between placebo and auditory stimulation naps. The MST involves pressing four numerically labeled keys on a standard keypad, repeating a 5 digit sequence as quickly and accurately as possible for 12 trials at 30 seconds each separated by 30 sec rest periods. Different sequences are employed for the placebo and stimulation visits in a counter-balanced order. |
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Inclusion Criteria:
For healthy controls:
For schizophrenia patients:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dara Manoach, PhD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
There is no plan to share IPD data.
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000161 | Acoustic Stimulation |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D026421 | Sensory Art Therapies |
| D000529 | Complementary Therapies |
| D010812 | Physical Stimulation |
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| Auditory Stimulation | Other | Auditory stimulation will be delivered during the nap |
|
| Placebo and auditory stimulation naps will be approximately one week apart |
| Differences in slow oscillations | Differences in slow oscillations during non-rapid eye movement (NREM) sleep as measured by EEG between placebo and auditory stimulation naps | Placebo and auditory stimulation naps will be approximately one week apart |
| Differences in sleep spindles | Differences in sleep spindles during non-rapid eye movement (NREM) sleep as measured by EEG between placebo and auditory stimulation naps | Placebo and auditory stimulation naps will be approximately one week apart |
| D008919 |
| Investigative Techniques |