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Using a point-of-care (POC) platform, the investigators will investigate the effects of POC testing for glycated hemoglobin (HbA1c) and cystatin C at out-patient clinics on long-term diabetes outcomes.
Laboratory testing for HbA1c and cystatin C is time-consuming, and healthcare providers often do not have update results when they evaluate outpatients with diabetes. A POC testing platform may help address this issue, and the investigators aim to examine its effects on diabetes outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Outpatients with diabetes who provide consent to POC testing | Experimental | Intervention: POC testing for HbA1c and cystatin C. Observational follow up: data on fasting glucose, HbA1c, serum creatinine, urine albumin to creatinine ratio (UACR), lipids profile, ...etc. |
|
| Outpatients with diabetes who decline to POC testing, but consent to observational follow up | No Intervention | This group will serve as the controls. Follow up data on fasting glucose, HbA1c, serum creatinine, urine albumin to creatinine ratio (UACR), lipids profile, ...etc. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| POC testing | Other | POC testing for HbA1c and cystatin C |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes from baseline to the end of study in eGFR | Estimated glomerular filtration rate (eGFR) will be determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (Levey AS, et al. Ann Intern Med. 2009; 150: 604-12). | Observational follow up period of 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Changes from baseline to the end of study in UACR | Observational follow up period of 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Incident chronic kidney disease | incident chronic kidney disease is defined as an eGFR <60 ml/min/1.73 m2 of at least 3 months duration. | Observational follow up period of 3 years |
Inclusion Criteria:
-Adults aged 18 to 80 receiving treatment and follow-up for diabetes at outpatient clinics of Taichung Veterans General Hospital, Taichung, Taiwan.
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taichung Veterans General Hospital | Taichung | 407219 | Taiwan |
Data will be available from the principal investigator on reasonable request.
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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The investigators will conduct POC testing for HbA1c and cystain C in outpatients with diabetes, and present the results to their providers. Follow up data on fasting glucose, HbA1c, serum creatinine, urine albumin to creatinine ratio (UACR), lipids profile, ...etc will be collected every 6 months for 3 years. Patients who decline to POC testing but provide consent to observational follow up will serve as the controls. The investigators will examine the effects of POC testing on changes in glycemic control and renal function in study participants.
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