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The purpose of the project is to investigate urine concentration after inhalation of salmeterol. This will be examined following acute physical activity under both normal conditions and heated conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal conditions | Active Comparator | Urine samples collected after various performance tests in normal conditions |
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| Heated conditions | Experimental | Urine samples collected after various performance tests in heated conditions |
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| Salmeterol inhalation and urine samples | Other | Participants are administered daily salmeterol inhalation from an MDI device and are required to collect spot urine samples at home. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal conditions | Other | Participants are administered salmeterol, after which they perform various performance tests in normal conditions. Following the administration of salmeterol, urine samples are collected over the next 24 hours at intervals of 0.5, 1, 2, 4, 8, and 24 hours after administration. |
| Measure | Description | Time Frame |
|---|---|---|
| Urine concentration | Difference in urine concentration with salmeterol administered before performance tests in different conditions | Through study completion, an average on 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Morten Hostrup, PhD | Contact | +4535321595 | mhostrup@nexs.ku.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| August Krogh Building | Recruiting | Copenhagen | 2100 | Denmark |
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| Heated conditions | Other | Participants are administered salmeterol, after which they perform various performance tests in heated conditions. Following the administration of salmeterol, urine samples are collected over the next 24 hours at intervals of 0.5, 1, 2, 4, 8, and 24 hours after administration. |
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| Salmeterol inhalation and urine samples | Drug | After the experimental day under normal conditions, all participants are administered 200 µg of salmeterol daily (8 puffs from the MDI device) during a 6-day intervention period. Two hours after inhalation, the participants collect spot urine samples at home |
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