Concentrations of Salmeterol in Blood and Urine

Blood and Urinary Concentrations of Inhaled Salmeterol in Asthmatic Subjects and Elite Athletes With Asthma.

The purpose of the study is to assess the blood and urine concentrations of inhaled salmeterol.

The purpose of the study is to assess the serum and urine concentrations of salmeterol after inhalation of 100 microgram salmeterol in one dose.

Furthermore, to evaluate any difference in three groups: 10 healthy men, 10 male asthmatic subjects and 10 male elite athletes with asthma.

Inclusion Criteria:

• Physician-diagnosed asthma with positive reversibility or challenge test.
• Informed consent.
• Age between 18-45 years.
• Sex: male.
• Asthma classified as mild to moderate according to GINA guidelines.
• Used beta-2-agonist in minimum 12 months.

Exclusion Criteria:

• Smokers or ex-smokers with a smoking history of 10 pack years or more.
• Respiratory tract infections within the last 2 weeks prior to study day.
• Subjects with other chronic diseases than asthma and/or allergy.
• Allergy towards the study medicine.
• Use of beta-2-agonist 10 days prior to study day.