Concentrations of Formoterol in Blood and Urine

Blood and Urinary Concentrations of Inhaled Formoterol in Asthmatic Subjects and Elite Athletes With Asthma

The purpose of the study is to assess the blood and urine concentrations of inhaled formoterol.

The purpose of the study is to assess the serum and urine concentrations after inhalation of 18 microgram formoterol as one dose.

Furthermore to investigate the serum and urine concentrations of inhaled formoterol and evaluate the difference between three groups: healthy men, male asthmatic subjects and male elite athletes with asthma.

Inclusion Criteria:

• Physician-diagnosed asthma with positive reversibility or challenge test.
• Informed consent.
• Age between 18-45 years.
• Sex: male.
• Asthma classified as mild to moderate according to GINA guidelines.
• Used beta-2-agonist in minimum 12 months.

Exclusion Criteria:

• Smokers or ex-smokers with a smoking history of 10 pack years or more.
• Respiratory tract infections within the last 2 weeks prior to study day.
• Subjects with other chronic diseases than asthma and allergy.
• Allergy towards the study medicine.
• Use of beta-2-agonist 10 days prior to study day.