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This project aims to conduct safety and efficacy tests on the skin for the ingestion of Astrion Vitality Capsules, containing A. membranaceus and C. Asiatica roots, and the topical application of Astrion Vitality Cream. The goal is to develop health and skincare products that regulate physiological functions, promote overall wellness, and enhance skin beauty.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ACS Topical Treatment Group | Experimental | 25 participants, measured at Week 0, 2, 4. |
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| Topical Placebo Group | Placebo Comparator | 25 participants, measured at Week 0, 2, 4. |
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| ACS Oral Treatment Group | Experimental | 25 participants, measured at Week 0, 2, 4, 8, 12. |
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| Oral Placebo Group | Placebo Comparator | 25 participants, measured at Week 0, 2, 4, 8, 12. |
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| ACS Oral Treatment + ACS Topical Treatment Group | Experimental | 25 participants, measured at Week 0, 2, 4, 8, 12. |
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| ACS Oral Treatment + Topical Placebo Group | Placebo Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ACS Topical Treatment Group | Dietary Supplement | The topical group applied the ACS cream to the face twice daily (morning and night) for 4 weeks. |
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| Measure | Description | Time Frame |
|---|---|---|
| skin melanin | Skin elastometer (Soft Plus) was utilized to measure skin melanin. Units: arbitrary units | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit |
| Skin brightness | Skin color difference analyzer (Chroma Meter MM500) was utilized to measure skin brightness | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit |
| skin moisture | Skin moisture meter (Corneometer CM825) was utilized to measure skin moisture. Units: arbitrary units | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit |
| skin elasticity | Skin elastometer (Soft Plus) was utilized to measure skin elasticity. Units: arbitrary units | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit |
| collagen density content | Subcutaneous collagen scanner (DermaLab® Series SkinLab Combo) was utilized to measure skin collagen. Units: arbitrary units | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chia Nan University of Pharmacy ＆ Science | Tainan | 71710 | Taiwan |
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| ID | Term |
|---|---|
| D010859 | Pigmentation Disorders |
| D004890 | Erythema |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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25 participants, measured at Week 0, 2, 4, 8, 12. |
|
| Topical Placebo Group | Dietary Supplement | The topical group applied the cream (without ACS) to the face twice daily (morning and night) for 4 weeks. |
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| Oral Treatment + Topical Treatment Group | Dietary Supplement | The combination group used both the topical and oral ACS products for 12 weeks. |
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| ACS Oral Treatment Group | Dietary Supplement | The oral group ingested one ACS capsule twice daily after breakfast and dinner for 12 weeks. |
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| Oral Placebo Group | Dietary Supplement | The oral group ingested one capsule (without ACS) twice daily after breakfast and dinner for 12 weeks. |
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| Oral Treatment + Topical Placebo Group | Dietary Supplement | The combination group used both the topical and oral products without ACS for 12 weeks. |
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| skin surface topography | VISIA Micro-Analysis Skin Image Analyzer was utilized to measure skin texture. Units: arbitrary units | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit |
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |