Evaluate and compare the effects on female facial skin of oral placebo (Product A), N-acetylneuraminic acid (Product B), and ACAI-PLUS (Product C) after 28, 56, and 84 days under normal usage conditions.

Inclusion Criteria:

• Skin type origin: Asian in China

• Age: from 40 to 65 years old

• Gender: female

• Specific criteria:

  • All skin type on the face Dry, dry combination, normal

  1. presenting with a lack of elasticity to the face, inclusion grade

     ≤ 6 according 10 points scale

  2. presenting with a lack of density to the face, inclusion grade ≤ 6 according 10 points scale

  3. presenting with wrinkles on crow's feet area, grade ≥ 2 according to Skin ageing atlas Vol.2 (p.41)

  4. presenting with pigmentary spots with at least one with diameter ≥ 3mm

• Usual or occasional user of food supplements

• Able to give her informed consent

Exclusion Criteria:

The non-inclusion general criteria were the following ones:

• allergies or reactivity to cosmetic products,
• for the subjects undergoing hormonal treatment; change of treatment within 3 months preceding the inclusion visit,
• expectation of change in the current hormonal treatment during the study,
• anti-allergic, antibiotic, anti-inflammatory, dermatological treatment or corticosteroid therapy within 2 weeks before the inclusion visit,
• having a chronic pathology,
• performing or prevision to perform another test during the study or during the exclusion period,
• employee of the COSderma laboratory,
• pregnant or breast-feeding woman,
• woman not taking precaution to prevent pregnancy.

The non-inclusion specific criteria were the following ones:

• application of care products to the face within 48 hours preceding the inclusion visit,
• application of make-up products to the face the day of the inclusion visit,
• face wash with any other means than clear water (no soap or cleanser) on the day of the inclusion visit,
• application of self-tanning products to the face within 4 weeks preceding the inclusion visit,
• Oral intake of food supplement within 1 month preceding the inclusion visit,
• cutaneous marks on the face which could interfere with the skin's clinical signs assessment (pigmentation issues, scar tissues, over-developed hairiness, too many ephelides and naevi, sunburns...),
• solar exposition (natural sun or UVA or heliotherapy treatment) within 4 weeks preceding the inclusion visit and expectation of solar exposition (natural or UVA) during the study,
• Vitamin A acid treatment or its derivatives within 3 months preceding the pre-inclusion visit,
• Retinoid based oral treatment within 6 months before the pre-inclusion visit, or local treatment within 2 months prior to this visit,
• Carotene based treatment within 4 weeks preceding the inclusion visit,
• expectation or having undergone aesthetic or dermatological surgery on the face.

Chinese Asian women aged 40-65, with facial skin issues such as pigmentation spots, lack of elasticity, and wrinkles