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The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question[s] it aims to answer are:
Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks
The elderly population in West Java Province with the age category of 60-64 years is 1.76 million people. Experts estimate that 25.2% of the Indonesian population experiences frailty. Frailty can lead to a variety of worsening health conditions. The frailty process is thought to stem from the failure of various mechanisms associated with markers of aging. Markers of aging are divided into three categories: primary, antagonistic and integrative. Biomarkers representing these three categories are global DNA methylation, GDF15 and Lamin A COP. Multicomponent exercise is the most effective intervention in elderly with frailty. Elderly people in West Java on average only have an education equivalent to junior high school (SMP), so activities that promote physical activity are better focused on health activities in the community. The poco-poco exercise that is currently commonly practiced almost fulfills the rules of multicomponent exercise for frailty elderly, but poco-poco exercise does not have a muscle strengthening exercise component, so a modified poco-pcoco exercise was created to fulfill this method.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Frail elderly living in community | Experimental | Adult above 60 years old, frailty level based on Fried frailty phenotype, without having diabetes mellitus and cardiac disease |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EXERCISE TRAINING WITH OR WITHOUT MEDICATION | Other | Exercise training that consists of flexibility, aerobic, balance and strengthening regime. The exercise given three times a week, for 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline in Level of Global DNA Methylation in 12 Weeks | Global DNA Methylation will be measured twice using ... | week 0 and week 12 |
| Change From Baseline in Level of Growth Deficiency Factor (GDF15) in 12 Weeks | GDF15 will be measured using blood plasma with Enzyme Linked Immuno Assay (ELISA), expected GDF value that show improvement that it will be decreased | week 0 and week 12 |
| Change From Baseline in Level of Lamin A (Cyclic Osteo Progenitor) COP in 12 Weeks | Lamin A COP will be measured with flow cytometry from Peripheral Blood Mononuclear Cells (PBMC), the value that shows improvement has a lesser lamin A COP population | week 0 and week 12 |
| Change From Baseline in Level of Frailty in 12 Weeks | Level of Frailty is measured using Fried's Frailty Phenotype with range 1-5 with 5 is the worst level of frailty. Fried's frailty measured with five components that are unintentional weight loss, muscle weakness, exhaustion on activity, slow gait and low physical activity. | week 0 and week 12 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Istingadah Desiana, dr, SpKFR, Ger(K), FIPM (USG) | Contact | 62 812 7123 9200 | istingadah.desiana@unpad.ac.id | |
| William Giovani, dr | Contact | 6281271239200 | williamgiovanni146@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Irma R. Defi, DR. Med. Sc, dr, SpKFR, Ger(K) | Faculty of Medicine Universitas Padjadjaran | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Puskesmas Sekejati | Recruiting | Bandung | West Java | 40287 | Indonesia |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D004304 | Dosage Forms |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| D004364 | Pharmaceutical Preparations |
| D013678 | Technology, Pharmaceutical |
| D008919 | Investigative Techniques |