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End of collaboration with research site.
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The goal of this observational study is to learn about egg physiology in humans.
The main question it aims to answer is if there is an association between egg physiology and egg quality.
Discarded, unfertilised eggs and follicular fluid collected during routine egg retrieval from participants undergoing in vitro fertilisation (IVF) as part of their regular medical care along with information from participants' electronic medical records will be collected and analysed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Women undergoing in-vitro fertilisation (IVF) with male factor diagnoses. |
| |
| Case Group | Women undergoing IVF with a diagnosis other than male factor. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Informative Appointment | Other | The only intervention involving the participants is non-clinical, which is an extra 30-minute informative telephone appointment added to the standard care consultation schedule of interested IVF patients where they will be presented with a digital consent PDF form to sign by a study nurse or clinically trained research personnel. Participants will be in the study for 24-30 months. During this time their discarded, unfertilised oocytes and follicular fluid collected during routine oocyte retrieval along with information from their electronic medical records will be collected and analysed. |
| Measure | Description | Time Frame |
|---|---|---|
| Mitochondrial physiology in the oocytes | Baseline time of observation which lasts between 1 and 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of oocyte mitochondrial physiology results to clinical outcomes to assess correlation (or lack thereof) | As the data becomes available over the course of the participants' medical treatment. E.g. From enrolment until birth of an infant |
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Inclusion Criteria:
Exclusion Criteria:
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People with uteri experiencing infertility issues requiring assisted reproduction via in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or undergoing elective egg freezing.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Avenues Clinic | London | NW1 1BU | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23953328 | Background | Brayboy LM, Oulhen N, Witmyer J, Robins J, Carson S, Wessel GM. Multidrug-resistant transport activity protects oocytes from chemotherapeutic agents and changes during oocyte maturation. Fertil Steril. 2013 Nov;100(5):1428-35. doi: 10.1016/j.fertnstert.2013.07.002. Epub 2013 Aug 13. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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Discarded, unfertilised oocytes and follicular fluid collected during routine oocyte retrieval
|