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The goal of this observational study is to understand the processes in the growing follicles development in more detail and to improve In Vitro Fertilisation (IVF) treatments. This involves measuring laboratory values in the blood, in the follicular fluid of the woman and in the sperm of the man as well as questionnaires concerning lifestyle factors. These values are then linked to the success of the fertility treatment to find out which of these values increase the success of the IVF treatment.
Furthermore, the investigators want to investigate if there are differences between IVF treatments with or without hormonal stimulation of the ovaries.
This is a one-site prospective exploratory study at the University Clinic for Gynaecological Endocrinology and Reproductive Medicine in Bern. Data of influencing factors on IVF success in women and men will be collected in two types of IVF treatment, i.e. with or without hormonal stimulation of the ovaries.
The investigators want to
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| In Vitro Fertilisation (IVF)-Patients without hormonal stimulation (Natural cycle IVF) | Natural cycle IVF |
| |
| In Vitro Fertilisation (IVF)-Patients with hormonal stimulation (conventional IVF) | conventional IVF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Natural cycle In Vitro Fertilisation (IVF) | Procedure | In Vitro Fertilisation (IVF) without hormonal stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blastocyst rate per oocyte | Number of blastocysts out of fertilized oocytes observed 5 days after fertilization | 5 days after fertilization |
| Measure | Description | Time Frame |
|---|---|---|
| Number of mature oocytes | Number of mature oocytes from punctured follicles | 4-6 hours after punction |
| Cleavage rate per oocyte | Number of cleavage embryos out of fertilized oocytes observed 2 days after fertilization |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aiming to do In Vitro Fertilisation with fresh embryo transfer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Janna Pape, MD | Contact | 0041316321010 | janna.pape@insel.ch | |
| Michael von Wolff, Prof. Dr. | Contact | 0041316321301 | michael.vonwolff@insel.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inselspital Bern, Frauenklinik | Recruiting | Bern | 3010 | Switzerland |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D003226 | Congresses as Topic |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Follicular fluid; serum
| Blood samples for analysis | Diagnostic Test | Test hormone levels in serum |
|
| Follicular fluid for analysis | Diagnostic Test | Test hormone levels in follicular fluid Test Oxidation-reduction potential |
|
| Sperm samples for analysis | Diagnostic Test | Oxidation-reduction potential |
|
| Conventional In Vitro Fertilisation (IVF) | Procedure | In Vitro Fertilisation (IVF) with conventional hormonal stimulation |
|
| 2 days after fertilization |
| Morphologic evaluation of blastocyst | Morphologic evaluation according to the Gardner score (Gardner and Schoolcraft, 1999) | 5 days after fertilization |
| Implantation rate | Endocrine pregnancy by measuring hCG in blood sample on day 10-12 after embryo transfer | 10-12 days after embryo transfer |
| Clinical pregnancy rate | Clinical pregnancy confirmed by ultrasound, 5 weeks after embryo transfer. | 5 weeks after embryo transfer |
| Live birth rate | Birth of a living baby nine months after embryo transfer | 9 months after embryo transfer |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D009938 | Organizations |
| D004472 | Health Care Economics and Organizations |