• Spontaneous Coronary Artery Dissection National Swiss Registry

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• International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry

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• The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry

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• Canadian SCAD Study

  NCT02188069

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• Spontaneous Coronary Artery Dissection Registry (DIssezioni Spontanee COronariche ITalian-SPAnish)

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• Spanish Registry on Spontaneous Coronary Artery Dissection

  NCT03607981

  Unknown statusObservationalUpdated Aug 2, 2018

ClinicalTrials.gov ID

NCT06601270

Lead Sponsor

European Society of CardiologyNETWORK

Overall Status

Recruiting

Study Type

Observational

Enrollment

1,500Estimated

Last Update Posted

Oct 29, 2024Actual

Start Date

Jan 30, 2021Actual

Primary Completion Date

Oct 2026Estimated

Completion Date

Oct 2027Estimated

Official Title

A Registry of Spontaneous Coronary Artery Dissection

Brief Summary

Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors. Knowledge of SCAD has advanced considerably in the last few years as a result of data from a number of local and national registries 1-6. Like all rarer diseases however, a better understanding of SCAD will require international collaboration. At present, there is no European or International SCAD registry despite increasing recognition that there are key differences in the diagnosis, interventional and medical management of SCAD compared with conventional atherosclerotic ACS. The ESC-ACCA Study Group on Spontaneous Coronary Artery Dissection supported by the European Observational Research Programme will now build the first pan-European SCAD registry to advance our understanding of current management of this condition, inform guidelines, educate clinical colleagues and advance research.

Detailed Description

Observational, multicentre, international retrospective and prospective cohort study.

Since this is an observational study, a formal sample size is not necessary. At least 500 prospectively recruited patients and 500 historical cases will be enrolled.

Patient data will be collected at the following time-points:

• First SCAD event visit (retrospectively on chart review)
• First follow-up: at time of enrolment
• Yearly follow-up: up to 1, 2, 3, 4 and 5 years post enrolment or until study completion

Approximately 30 countries and 120 sites will participate in this registry.

• Spontaneous Coronary Artery Dissection

• There are no interventions as the study is purely observational.

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Patient having signed an Informed Consent
• Patient aged 18 years and over
• SCAD clinical diagnosis within the past 10 years and available coronary angiographic imagery

Exclusion Criteria:

• Patient unwilling or unable to consent
• Patients with iatrogenic or atherosclerotic coronary dissection

Observational Model

Cohort

Time Perspective

Other

Lead Sponsor

European Society of CardiologyNETWORK

Francis.stammen@azdelta.be003251237277