Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to determine how effectively bone structures of the human skeleton can be visualized using Deep Learning (DL) augmented Magnetic Resonance Imaging (MRI) in individuals with inflammatory and degenerative joint changes, compared to Computed Tomography (CT). MRI is a technique that operates without the use of X-rays. The main question it aims to answer is:
Researchers will compare DL MRI scans to CT scans to see if DL MRI can effectively replace CT in visualizing bone structures without the use of radiation.
Participants will:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low Dose Computer Tomography | Radiation | Participants will undergo MRI scans of their skeletal system, followed by the Intervention of a Low Dose CT scan of the same body region for comparison purposes. |
| Measure | Description | Time Frame |
|---|---|---|
| Total score for bone erosions | Each bone is scored separately. The scale is 0-10, based on the proportion of eroded bone compared to the "assessed bone volume," judged on all available images: 0: no erosion; 1: 1-10% of bone eroded; 2: 11-20%, etc. For long bones, the "assessed bone volume" is from the articular surface (or its best estimated position if absent) to a depth of 1 cm, while in carpal/tarsal bones it is the whole bone. Example of bone list for hands: carpal bones, distal radius, distal ulna, metacarpal bases; metacarpophalangeal, MCP, joints: metacarpal head, phalangeal base; maximum points: 230. A higher score means more bone erosions. Note: The total score will vary according to body area imaged, this will be taken into account in the final analysis. | one day (day of MRI and CT examination) |
| Total score for joint space narrowing | 0: no narrowing, 1: focal or mild (< 33%), 2: moderate (34-66%), 3: moderate to severe (67-99%), 4: ankylosis A higher score means more joint space narrowing. Note: The total score will vary according to body area imaged, this will be taken into account in the final analysis. | one day (day of MRI and CT examination) |
| Visibility of cortical bone | Scale from 1 to 4
A higher score means better image quality. | one day (day of MRI and CT examination) |
| Visibility of trabecular bone | Scale from 1 to 4
A higher score means better image quality. | one day (day of MRI and CT examination) |
| Visibility of soft tissue calcifications | Scale from 1 to 4
A higher score means better image quality. |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carina Obermüller, Dr. med. | Contact | 0041763654453 | carina.obermueller@usz.ch | |
| Roman Guggenberger, PD Prof. Dr. med. | Contact | roman.guggenberger@ksw.ch |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich | Recruiting | Zurich | 8091 | Switzerland |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The radiologists who perform the readout will be blinded to the reference low dose CT scan to avoid being primed for certain bony anatomy and pathology by evaluating the low dose CT first. The reference low dose CT scan will be read in a separate session.
| one day (day of MRI and CT examination) |
| Contrast to noise ratio | Average signal of erosion minus average signal of adjacent healthy bone, divided by the average background signal A higher score means better contrast of erosions when standardized for healthy adjacent bone and against the background. | one day (day of MRI and CT examination) |
| Signal to noise ratio | Average signal of erosion divided by the average background signal A higher score means better contrast of erosions against the background. | one day (day of MRI and CT examination) |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D001168 | Arthritis |
| ID | Term |
|---|---|
| D009140 | Musculoskeletal Diseases |
Not provided
Not provided