An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are:

• To describe characteristics such as demographics, co-morbidities and environmental exposures
• To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible
• To describe participant outcomes such as cancer stage, treatment and mortality
• To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data.

Participants will currently have no change to their usual care.

Inclusion Criteria:

• All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site

Exclusion Criteria:

• Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:

  • More than 100 cigarettes or 75g tobacco in their lifetime
  • Those who have received a prescription for nicotine replacement therapy

• For prospective participants, those who cannot consent will be excluded