The purpose of this study is to determine if collecting information and blood from a group of people who never smoked but who have lung cancer, is possible across the US. The investigators will collect information on each patient's diagnosis and treatments. If the collection is successful, blood samples will be used to try to identify new genes (which are the basic elements of heredity, passed from parents to their offspring), which may explain and predict why certain patients develop lung cancer without having smoked tobacco.

Inclusion Criteria:

• 18 years or older
• histologically and/or cytologically proven diagnosis of non-small cell lung cancer
• never smoker, defined as having smoked less than 100 cigarettes over one's life-time
• completed survey and inclusion form
• signed informed consent

Exclusion Criteria:

• previous history of cancer (other than lung cancer)
• living outside the United States
• patients who cannot read English (as website and questionnaires will only be written in English)
• unable to understand the protocol or to give informed consent

Never-smokers with lung cancer

Internet recruitment The study will be advertised through a specifically designed website linked to the MSKCC Lung Cancer webpage. The website will be designed after approval of the study. The website will be accordingly reviewed by the IRB. We plan to advertise this study by word-of mouth at scientific meetings and on patient associations' websites and/or bulletins, with permission. The website will post a description of the study and an invitation to participate.

Interested patients will be given an email or mail address and/or phone number 866-854-4652 to contact MSKCC investigators about the study.