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The present study will be conducted to assess whether there is a direct benefit associated with modified-Graham's omentopexy (MGO), above and beyond the benefit associated with Graham's omentopexy (GO) in the treatment of perforated duodenal ulcers. We attempted to answer the question whether primary closure of the perforation in MGO will affect the outcome of surgery. Complication rates will be compared for the two alternative surgical procedures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SUTURE-CLOSURE OMENTOPEXY IN REPAIR OF PERFORATED PEPTIC ULCER | Active Comparator | Group (A ) includes modification of the Graham's patch will be used in this group, where suitable sutures are passed between the edges of perforation and tied to close the perforation. A pedicle of omentum based on right omental artery is brought between these sutures, and these sutures are tied again with pedicle of omentum between knots over the perforation (thus the omentum remains sandwiched between the two levels of secured knots). |
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| OMENTOPEXY ALONE IN REPAIR OF PERFORATED PEPTIC ULCER | Active Comparator | Group (B) includes Grahm's technique of omentopexy will be performed by closing the perforation by placing interrupted full thickness suitable sutures along the margins of the ulcer with a patch of pedicled omentum laid over these sutures, which are then tied (without any attempt for primary closure of the perforation before placing the omentum as a plug). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SUTURE-CLOSURE OMENTOPEXY IN REPAIR OF PERFORATED PEPTIC ULCER | Procedure | Patients presented with perforated peptic ulcer will be repaired using full thickness suture closure using 3/0 vicryl suture then omental patch laied over the sutures. |
| Measure | Description | Time Frame |
|---|---|---|
| Early postoperative follow up for repair of perforated peptic ulcer | resumption of oral intake | Three days after the operation |
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Inclusion Criteria:
- All adult patients of both sexes with a clinical diagnosis of perforated peptic ulcer (gastric or duodenal) that are fit to undergo surgery.
Exclusion Criteria:
- 1. Patients with associated bleeding ulcer (additional steps are needed to control bleeding).
2. Patients with associated pathology other than perforated peptic ulcer that needs surgical intervention.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adel A Abdrabou, Resident | Contact | 01014910091 | adelosman3399@gmail.com | |
| Asem Elsani M Ali, Professor | Contact | 0100 2613245 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university Hospital | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 2742484 | Background | Berne TV, Donovan AJ. Nonoperative treatment of perforated duodenal ulcer. Arch Surg. 1989 Jul;124(7):830-2. doi: 10.1001/archsurg.1989.01410070084017. | |
| 3800459 | Background | Boey J, Choi SK, Poon A, Alagaratnam TT. Risk stratification in perforated duodenal ulcers. A prospective validation of predictive factors. Ann Surg. 1987 Jan;205(1):22-6. doi: 10.1097/00000658-198701000-00005. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 10, 2025 | |
| Reset | Jul 29, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 10, 2025 | Jul 29, 2025 |
| ID | Term |
|---|---|
| D010439 | Peptic Ulcer Perforation |
| ID | Term |
|---|---|
| D010437 | Peptic Ulcer |
| D004378 | Duodenal Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| OMENTOPEXY ALONE IN REPAIR OF PERFORATED PEPTIC ULCER | Procedure | Patients presented with perforated peptic ulcer will be repaired by using omental patch without any attempt for primary closure of perforation. |
|
| 28138363 | Background | Chung KT, Shelat VG. Perforated peptic ulcer - an update. World J Gastrointest Surg. 2017 Jan 27;9(1):1-12. doi: 10.4240/wjgs.v9.i1.1. |
| D004066 |
| Digestive System Diseases |
| D013272 | Stomach Diseases |