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The aim of this clinical trial is to compare the outcomes of open versus laparoscopic repair for perforated peptic ulcer and provide evidence-based guidance to the selection of the most appropriate operative technique at Sohag University Hospital. The study will include patients presented with perforated peptic ulcers as a complication of peptic ulcer disease during the period of study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| open repair of perforated peptic ulcer | Active Comparator | group (A) includes patients with perforated peptic ulcer that will be operated by open repair approach |
|
| laparoscopic repair of perforated peptic ulcer | Active Comparator | group (B) includes patients with perforated peptic ulcer that will be operated by laparoscopic repair approach |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| open repair of perforated peptic ulcer | Procedure | group (A) includes patients with perforated peptic ulcer that will be operated by open repair approach |
|
| Measure | Description | Time Frame |
|---|---|---|
| Early postoperative follow up for repair of perforated peptic ulcer | resumption of oral intake | 3 days after the operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hussam F Muhammad, Resident | Contact | 01090272797 | hossamfathyshabeb@gmail.com | |
| Ayman M Ahmad, Professor | Contact |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University Hospital | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28242110 | Background | Lanas A, Chan FKL. Peptic ulcer disease. Lancet. 2017 Aug 5;390(10094):613-624. doi: 10.1016/S0140-6736(16)32404-7. Epub 2017 Feb 25. | |
| 31921329 | Background | Tarasconi A, Coccolini F, Biffl WL, Tomasoni M, Ansaloni L, Picetti E, Molfino S, Shelat V, Cimbanassi S, Weber DG, Abu-Zidan FM, Campanile FC, Di Saverio S, Baiocchi GL, Casella C, Kelly MD, Kirkpatrick AW, Leppaniemi A, Moore EE, Peitzman A, Fraga GP, Ceresoli M, Maier RV, Wani I, Pattonieri V, Perrone G, Velmahos G, Sugrue M, Sartelli M, Kluger Y, Catena F. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg. 2020 Jan 7;15:3. doi: 10.1186/s13017-019-0283-9. eCollection 2020. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 30, 2025 | |
| Reset | Jul 17, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 30, 2025 | Jul 17, 2025 |
| ID | Term |
|---|---|
| D010439 | Peptic Ulcer Perforation |
| ID | Term |
|---|---|
| D010437 | Peptic Ulcer |
| D004378 | Duodenal Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| laparoscopic repair of perforated peptic ulcer | Procedure | group (B) includes patients with perforated peptic ulcer that will be operated by laparoscopic repair approach |
|
| 21494041 | Background | Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84(2):102-13. doi: 10.1159/000323958. Epub 2011 Apr 14. |
| D004066 |
| Digestive System Diseases |
| D013272 | Stomach Diseases |