Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery

Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery

Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.

Given the need for the use of experimental models that mimic the tumor of origin

Inclusion Criteria:

• over 18 years of age;
• diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides;
• availability of adequate material for the preparation of organoid cultures, derived from surgery;
• written informed consent.

Exclusion Criteria:

• previous chemotherapy treatments