Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.

Given the need for the use of experimental models that mimic the tumor of origin

Inclusion Criteria:

• over 18 years of age;
• diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides;
• availability of adequate material for the preparation of organoid cultures, derived from surgery;
• written informed consent.

Exclusion Criteria:

• previous chemotherapy treatments

Consecutive patients affected by GEP-NEN undergoing treatment will be enrolled in this study surgery to remove the tumor