Interventional (low intervention level), non-pharmacological, prospective, feasibility pilot study of the preparation of organoids starting from lung tumor tissue collected during biopsies performed via diagnostic bronchoscopy according to standard clinical practice.

Interventional, non-pharmacological, prospective, feasibility pilot study of the preparation of organoids starting from lung tumor tissue collected during biopsies performed via diagnostic bronchoscopy according to standard clinical practice. This protocol is classified as "interventional" (low intervention level) since that, if possible, an additional quantity of lung tumor tissue will be collected compared to that normally obtained as standard clinical practice, during bronchoscopy, al in order to increase the probability of successful generation of organoids. Involves the prospective recruitment of patients undergoing diagnostic bronchoscopies for suspected lung cancer.

Inclusion Criteria:

• patients with suspected diagnosis of centrally located and accessible lung cancer endoscopically;
• patients for whom it is indicated to undergo in-depth diagnostic testing through bronchoscopy for the purpose of determining the histotype of the lung neoplasm, according to clinical practice standard;
• aged over 18;
• patients who express informed consent to the study.

Exclusion Criteria:

• medical contraindication to taking biopsy samples;
• medical contraindication to carrying out endoscopic investigations;
• patients with suspected lung cancer not accessible endoscopically;
• patients with lung neoformation already subjected to diagnostic sampling;
• contraindications to taking an additional quantity of tissue.