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The core symptoms of post-traumatic stress disorder (PTSD) include flash backs, intrusive pictures and thoughts related to the traumatic event, hyperalertness, avoidance of traumatic relevant environmental triggers and emotional dysregulation. Some studies suggest that PTSD is also associated with impaired olfactory perception, which seems quite intuitive regarding the close anatomical-functional connections between olfactory and emotional circuits. Furthermore, some studies reported that olfactory stimuli can trigger flashbacks in subjects with PTSD. However, up to know available data is scarce and heterogeneous concerning that topic. The goal of the study is to determine the olfactory phenotype of subjects with PTSD. More precisely, this project aims at filling the above mentioned gap by systematically assessing the olfactory perception of subjects with PTSD along five dimensions: olfactory identity, hedonic value, familiarity, desirability and edibility. As a secondary goal, the relative weight of olfaction compared to the other senses in the relived memories of subjects with PTSD will be assessed.
The investigators here hypothesize a global impairment in olfactory processing (intensity, hedonicity, familiarity and edibility judgments) in PTSD subjects, compared with healthy subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with PTSD | They are outpatients receiving psychological and medical treatment in the clinical department connected to the inclusion site |
| |
| Control group | Data from subjects without PTSD included in a previous study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| European Test of Olfactory Capabilities (ETOC) | Behavioral | Investigators will collect the ETOC score in patient of both arms |
|
| Measure | Description | Time Frame |
|---|---|---|
| Standardized Hedonicity Test score | Results obtained in patients will be compared to those obtained in control group | at inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Effects of potential moderators on odor judgement | Analysis of covariance (ANCOVA) to determine the effect of different moderators (age, gender, type of trauma, time elapsed since trauma, type of treatment received, symptom intensity) on olfactory perception | at inclusion |
| Evaluation of sensory impressions of memories evoked by certain odors. |
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Inclusion Criteria:
Exclusion Criteria:
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patients aged 18 to 50 suffering from PTSD
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| VIGNAUD Philippe, MD, PhD | Contact | +33472116396 | philippe.vignaud@chu-lyon.fr | |
| GALIA Perrine, CRA | Contact | +33472111311 | perrine.galia@chu-lyon.fr |
| Name | Affiliation | Role |
|---|---|---|
| VIGNAUD Philippe, MD, PhD | Auvergne-Rhône-Alpes Regional Center for Psychotrauma | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Auvergne-Rhône-Alpes Regional Center for Psychotrauma | Lyon | 69003 | France |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| D000086582 | Anosmia |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
| D000857 | Olfaction Disorders |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D009812 | Odorants |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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| Standardized Hedonicity Test | Behavioral | To smell 20 odorant solutions and for each odor and evaluate it along five dimensions: familiarity, hedonicity, edibility, desire to smell again, perceived intensity). Each dimension is assessed with a Likert scale (from 1 (not at all) to 9 (extremely)) |
|
| Questionnaires | Behavioral | Patients with PTSD will have the following questionnaires : PTSD Checklist for Diagnostic and Statistical Manual (DSM)-V (PCL-5), Peri-trauma Dissociation Experience Questionnaire (PDEQ), Patient Health Questionnaire-9 (PHQ9), Snaith-Hamilton Pleasure Scale (SHAPS), Childhood Trauma Questionnaire (CTQ) and Apathy Evaluation Scale (AES) |
|
| Odor / trauma association questionnaire | Behavioral | Patients with PTSD will have Odor / trauma association questionnaire |
|
Sensory impressions: Nature and frequency of sensory descriptions associated with odor-evoked memories |
| at inclusion |
| Evaluation of emotional valence of memories evoked by certain odors. | Language analysis: Use of Natural Language Processing (NLP) techniques to assess the emotional valence of odor-evoked memories and recurrent themes in oral responses concerning evoked memories. Analysis of the association of trauma-related odors with the 5 senses | at inclusion |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D004777 | Environment |
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |