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Post-traumatic stress disorder is associated with altered processing of sensory stimuli. The clinical phenotype PTSD has predominantly been described for the visual and auditory sensory modalities. However, PTSD symptoms such as intrusive memories are often evoked by olfactory and tactile cues in the environment. Moreover, little is known about whether aberrant responses to social olfactory and tactile stimuli are also present in a subclinical population.The purpose of this study is to compare trauma-exposed subjects (e.g. childhood maltreatment) with non-exposed controls in the processing of olfactory and tactile stimuli. This sensory characterizations hold potential to identify potential biomarkers for the course of trauma-related disorders and to inform trauma therapies focusing on sensory integration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Individuals exposed to an intentional/non-intentional trauma |
| ||
| Healthy controls without trauma-exposure |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Processing of social olfactory and tactile stimuli | Behavioral | Processing of social olfactory and tactile stimuli in trauma-exposed individuals and controls is examined using functional magnetic resonance imaging. |
| Measure | Description | Time Frame |
|---|---|---|
| Emotion recognition ratings obtained during a forced-choice emotional face recognition task with stimuli of varying intensities (neutral to fearful). | Ratings will be assessed throughout fMRI scanning over the course of 25 minutes. | |
| Neural substrates of social tactile stimuli processing. | fMRI scanning will be used to measure neural respones to tactile stimuli. | The neural substrates will be assessed througout fMRI scanning over the course of 20 minutes. |
| Valence ratings of social tactile stimuli. | Ratings will be assessed throughout fMRI scanning over the course of 20 minutes. | |
| Neural substrates of social olfactory stimuli processing. | The neural substrates will be assessed througout fMRI scanning over the course of 25 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxytocin plasma concentrations. | The oxytocin plasma concentrations of all participants will be assessed 15 minutes before fMRI scanning onset.. | |
| Olfactory performance in a n-butanol odor staircase threshold test. | Participants' olfactory performance will be assessed by administering the 'Sniffin' Sticks' test, which measures nasal chemosensory performance based on pen-like odor dispensing devices. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population will consist of trauma-exposed subjects and healthy controls without trauma-exposure.Patients and healthy controls will be recruited from the Bonn area.
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| Name | Affiliation | Role |
|---|---|---|
| René Hurlemann, PhD, MD, MSc | Department of Psychiatry, University of Bonn, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, University of Bonn | Bonn | 53105 | Germany |
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| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| The olfactory threshold of all participants will be assessed in a screening session at least 24 hours prior to fMRI scanning. |