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A psychiatric diagnosis of post-traumatic stress disorder (PTSD) is currently based mainly on non-quantitative elements, such as interviews and subjective impressions. PTSD has physiological manifestations, some of which are likely reflected in the levels and ratios of certain stress-related proteins in the interstitial fluid and plasma. Discernable patterns of such stress-related proteins may constitute a biochemical phenotype characteristic of PTSD, which may serve as a biomarker and support diagnostic decisions, as well as personalized treatment plans.
The current study is a non-interventional observational study aimed at examining the possibility of basing a psychiatric diagnosis by measuring changes in the biochemical phenotype of participants with PTSD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants diagnosed with PTSD | |||
| Non-PTSD participants |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in cortisol levels | Changes in cortisol levels as measured by the adhesive biosensor patches | 3 months |
| Changes in c-reactive protein (CRP) | Changes in c-reactive protein (CRP) levels as measured by the adhesive biosensor patches | 3 months |
| Changes in Interleukin 6 (IL-6) levels | Changes in Interleukin 6 (IL-6) levels as measured by the adhesive biosensor patches | 3 months |
| Changes in N-terminal pro b-type Natriuretic Peptide (NT-proBNP) levels | Changes in N-terminal pro b-type Natriuretic Peptide (NT-proBNP) levels as measured by the adhesive biosensor patches | 3 months |
| Changes in 8-Oxo-2'-deoxyguanosine (8-oxo-dg) levels | Changes in 8-Oxo-2'-deoxyguanosine (8-oxo-dg) levels as measured by the adhesive biosensor patches | 3 months |
| Changes in volatile organic compounds (VOCs) levels | Changes in volatile organic compounds (VOCs) concentrations (hexanone, acetic acid, heptane, hexanal, 3-heptanone, hexanoic acid, heptanal and nonanal) as measured by the adhesive biosensor patches | 3 months |
| Changes in glucose levels | Changes in glucose levels as measured by the adhesive biosensor patches | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Adult (aged 18 and over) participants with and without PTSD
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| Correlations between biochemical changes and PTSD clinical symptoms | Correlations between biochemical changes and questionnaire data relating to PTSD clinical symptoms (CGI, CAPS, PHQ, PCL-5, PC-PTSD-5, LEC-5 and BARS). | 3 months |