Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups.

Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups. The objective of this study is to offer novel insights into the association between oral health and cerebrovascular disease occurrence while establishing a foundation for future research.

Inclusion Criteria:

• 1. Microbleeding/damage or rupture of small blood vessels in the brain has been diagnosed within the past 365 days 2. Have done nuclear magnetic examination and can provide nuclear magnetic results

Exclusion Criteria:

• Have received antibiotic quality within the last three months

small cerebral vessel disease