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The purpose of this prospective study is to determine the effect of non-surgical root canal treatment in chronic kidney disease patients and healthy patients with apical periodontitis.
It has been found that there is an association between prevalence of odontogenic infection and systemic diseases. An elevated level of systemic cytokines has been observed in conjunction with both AP and CKD . The proinflammatory status and impaired immune response associated with systemic diseases (chronic kidney disease ) can affect the reparative response of the dental pulp and periapical healing. One study observed significant positive relation between number of diagnosed AP and urea serum level . A 4.35-mg/dL increase in the urea serum level could be expected per 1-unit increase in the number of teeth with AP. Improving oral health care through nonsurgical endodontic treatment(NSET) may improve the systemic inflammatory status and improve renal function.
The aim of this prospective study is to determine the effect of non-surgical root canal treatment in chronic kidney disease patients and healthy patients with apical periodontitis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic kidney disease group | Experimental | Root canal treatment will be performed in teeth with apical periodontitis in chronic kidney disease patients and change in PAI score, eGFR and systemic markers will be checked. |
|
| Healthy group | Active Comparator | Root canal treatment will be performed in teeth with apical periodontitis in healthy patients and change in PAI score and systemic markers will be checked |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| root canal treatment in Ckd patients | Procedure | root canal treatment in teeth with apical periodontitis to observe periapical healing , and change in eGFR ,blood urea and creatinine and HSCRP |
| Measure | Description | Time Frame |
|---|---|---|
| Periapical Index(PAI) | Periodical status will be assessed in periodical radiograph and scoring of periapical index will be done according to size and periphery of peri-apical radiolucency with coding 1 to 5 | 12MONTHS |
| Measure | Description | Time Frame |
|---|---|---|
| eGFR | BY BLOOD SAMPLE measured in mL/min/1.73m2 | 3-6MONTHS |
| serum creatinine | BY BLOOD SAMPLE measured in mg/dL | 3-6MONTHS |
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Inclusion Criteria:
1- Known patient of Chronic Kidney Disease [CKD Stages 1,2,3,4,5 with mature permanent teeth.
2. Age18year or older . 3. ≥ to 12 natural teeth (excluding 3rd molars) 4 The periapical index (PAI) was used to evaluate the periapical status patients with PAI ≥3 are included in the study.
Exclusion Criteria:
Gender matched healthy control participants to the same gender chronic kidney disease individuals will be analyzed.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| SHWETA MITTAL, MDS | Contact | 9255596960 | shwetagoelendo@gmail.com | |
| SANJAY TEWARI, MDS | Contact | 01262-283876 | principalpgids@yahoo.in |
| Name | Affiliation | Role |
|---|---|---|
| HIMANSHI VERMA, MDS | PGIDS,ROHTAK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| PGIDS | Recruiting | Rohtak | Haryana | 121004 | India |
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| root canal treatment in healthy patients | Procedure | root canal treatment in teeth with apical periodontitis to observe periapical healing and change in HSCRP |
|
| hs-CRP | HIGH SENSITIVE C-reactive protein measured by ELISA kit in mg/L | 3-6MONTHS |
| Blood urea | measured by collecting blood sample in mg/dL | 3-6MONTHS |
| ID | Term |
|---|---|
| D010485 | Periapical Periodontitis |
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D010483 | Periapical Diseases |
| D007571 | Jaw Diseases |
| D009057 | Stomatognathic Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D010518 | Periodontitis |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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