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Periodontal disease is a bacterially-induced inflammation. As such, it can become a point of entry of bacteria, toxins and cytokines into the systemic blood circulation, thus adversely affecting the function of kidneys. This is turn can aggravate the condition of patients with CKD.
The study hypothesis is that periodontal therapy can improve renal function in patients with CKD and lower the blood levels of markers for systemic inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Full mouth supra-gingival debridement using hand instruments and ultrasonic scalers, in one session. Patient motivation and oral hygiene instructions Review and prophylaxis at 1 month, 3 months and 6 months after initial treatment session. Full mouth periodontal therapy provided at the end of the 6month period (supra and sub- gingival full mouth scaling) | |
| Test/ Non-surgical Periodontal Therapy | Active Comparator | Full mouth periodontal therapy (sub and supra- gingival debridement) provided under local anaesthesia in two half-mouth sessions. Review and prophylaxis 1 month, 3 months and 6 months after the end of the initial therapy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Full Mouth Non-Surgical Periodontal Therapy | Procedure | Non-surgical Periodontal Therapy provided in two sessions, one for the right half and one for the left half of the dentition. Treatment sessions are provided within one week. No antibiotics or other adjunctive medications are to be used |
| Measure | Description | Time Frame |
|---|---|---|
| eGFR | Estimated Glomerular Filtration Rate | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| CRP | C-Reactive Protein level | 6 months |
| d-8-iso prostaglandin F2a | d-8-iso prostaglandin F2a | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Periodontal Indices (PPD, CAL, BOP, GI) | Assessment of the periodontal status | 6 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Phoebus N Madianos, PhD | University of Athens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Athens, Dental School, Department of Periodontology | Athens | 11527 | Greece |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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|
| Level of IgG antibodies in serum against periodontal pathogens | Serum samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "checkerboard immunoblotting" method: Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Treponema denticola, Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Campylobacter rectus, Eikenella corrodens, Peptostreptococcus micros, Veillonella parvula, Capnocytophaga ochracea, Streptococcus intermedius, Streptococcus sanguis και Streptococcus oralis.per | 6 months |
| Composition of dental plaque | Samples of subgingival plaque will be assessed using DNA probes according to the "checkerboard DNA- DNA hybridization" method. DNA probes will be used against the following bacteria: Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Treponema denticola, Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Campylobacter rectus, Eikenella corrodens, Peptostreptococcus micros, Veillonella parvula, Capnocytophaga ochracea, Streptococcus intermedius, Streptococcus sanguis and Streptococcus oralis | 6 months |
| HbA1C | Glycosylated Hemoglobin | 6 months |
| FMD / NMD | Flow Mediated Dialation, Nitroglycerin Mediated Dialation, Assessment of Endothelial Dysfunction | 6 months |
| PWV | Pass Wave Velocity, Assessment of Endothelial Dysfunction | 6 months |
| AIx | Augmentaion Index | 6 months |
| Cholesterol levels | Chloesterol Levels | 6 months |
| Ca | Serum Calcium | 6 months |
| P | Serum Phosphate | 6 months |
| Triglycerides | Serum triglycerides | 6 months |
| LDL / HDL | Low / High Density Lipoprotein | 6 months |
| Serum Urea | Serum Urea | 6 months |
| Serum Albumin | Serum Albumin | 6 months |
| Urine Albumin | Urine Albumin | 6 months |
| Urine Creatinine | Urine Creatinine | 6 months |
| Cr/Alb ratio | Urine Creatinine / Albumin Ration | 6 months |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |