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Objectives: This study investigates the effects of daily consumption of probiotic ayran drink on gingival inflammation and the development of experimental gingivitis.
Methods: A total of 54volunteer students were included in the present randomized, double-blind, placebo-controlled trial.The participants were divided randomly into two groups; The Control group consisted of 27 participants who consumed placebo ayran, while the 27 participants of the Test group consumed probiotic ayran (containing Lactobacillus acidophilus and Bifidobacterium bifidum) for 42 days twice a day.After 42 days, mechanical plaque control was interrupted for 5 days. The clinical parameters of gingivitis; Plaque index (PI), gingival index (GI), probing bleeding (BOP), probing depth (PPD) were recorded at baseline, day 42 (beginning of experimental gingivitis) and day 47 (the end of experimental gingivitis). At the same time points, gingival crevicular fluid had been collected for analysis of matrix metalloproteinase - 8 (MMP-8).
The most used and studied probiotics in the periodontal literature are lactobacillus and bifidobacterium. The current study aims to observe the effects of daily ayran consumption containing a probiotic combination of Lactobacillus acidophilus and Bifidobacterium bifidum on plaque development and gingival inflammation in an experimental gingivitis model of healthy individuals. The null hypothesis of this study using of probiotics has no additional benefit for periodontal health.
This study evaluates the effects of daily consumption of ayran containing a probiotic combination of Lactobacillus Acidophilus and Bifidobacterium Bifidum on plaque development and gingival status in healthy individuals with experimental gingivitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotic ayran drink | Experimental | The participants in this experimental group will use probiotic containing ayran for 42 days and then will be subjected to 5 days of experimental gingivitis. |
|
| Placebo ayran drink | Placebo Comparator | The participants in this control group will use control ayran without probiotics for 42 days and then will be subjected to 5 days of experimental gingivitis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| probiotic ayran drink | Dietary Supplement | The test group has received probiotic ayran drink for 6 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plaque index | PI was scored from 0 to 5 according to the color change obtained with the Mira-2 solution | Plaque index will be recorded at baseline, at day 42 and 47 |
| Gingival index | GI is graded by visual assessment and mechanical stimulation of the gingival tissues, scoring the gingival condition according to the criteria | Gingival index will be recorded at baseline, at day 42 and 47 |
| Bleeding on probing | The probing bleeding (BOP) index was determined by the presence/absence of bleeding ≈30 seconds after probing | BOP will be recorded at baseline, at day 42 and 47 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cenk Haytac, phd | Professor Doctor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cukurova University Faculty of Dentistry | Adana | Turkey (Türkiye) |
The data will be shared upon request
The data is ready and can be shared for two years
The data will be shared upon request
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| Placebo ayran drink | Dietary Supplement | The control group has received placebo ayran drink for 6 weeks |
|
| D009057 |
| Stomatognathic Diseases |