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| ID | Type | Description | Link |
|---|---|---|---|
| 6268 | Other Grant/Funding Number | Gazi University Project of Science Investigation |
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In this randomized controlled trial, it was aimed to evaluate the effect of probiotics (chewable tablets) and kefir consumption in the initial periodontal treatment of periodontitis patients on the change of oral microbiota and treatment. In this clinical trial, 36 systemically healthy volunteers who were diagnosed with periodontitis who were admitted to Gazi University Faculty of Dentistry, Department of Periodontology were included. Besides the inclusion criteria, the nutritional habits of the patients were evaluated by questionnaire. For diagnosis, plaque index, gingival index, bleeding on probing, periodontal probing depth and clinical attachment level were examined. Patients were randomly divided into 3 groups; probiotic, kefir and control group. Following the periodontal diagnosis, clinical index records of the patients and subgingival microbial samples were obtained. The supragingival plaque sample was removed and the subgingival microbial dental plaque sample was gently taken with a sterile Gracey curette. In the same session, periodontal initial treatment was started. According to the groups, they were involved simultaneously with the treatment, kefir group was advised to consume kefir as a liquid once a day in 14 days; probiotics group was advised to consume as a chewable tablet once a day in 14 days; the control group was advised without additional food supplements. Periodontal indexes were repeated in the 1st and 3rd months. Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia (T. forsythia), Porphyromonas gingivalis (P. gingivalis), and Treponema denticola (T. denticola).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotics | Experimental | The probiotics group was advised to consume a chewable tablet once a day in 14 days. |
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| Kefir | Experimental | The kefir group was advised to consume kefir as a liquid once a day in 14 days. |
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| Control | Other | the control group was advised without additional food supplements. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotics | Dietary Supplement | According to the groups, they were involved simultaneously with the treatment, kefir group was advised to consume kefir as a liquid once a day in 14 days; the probiotics group was advised to consume as a chewable tablet once a day in 14 days; the control group was advised without additional food supplements. |
| Measure | Description | Time Frame |
|---|---|---|
| Periodontal probing depth | the distance from the gingival margin to pocket base. | Baseline |
| Periodontal probing depth | the distance from the gingival margin to pocket base. | 1st month |
| Periodontal probing depth | the distance from the gingival margin to pocket base. | 3rd month |
| Gingival index | It is an index that shows the severity and quantity of gingival inflammation. | Baseline |
| Gingival index | It is an index that shows the severity and quantity of gingival inflammation. | 1st month |
| Gingival index | It is an index that shows the severity and quantity of gingival inflammation. | 3rd month |
| Microbiological sample | Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola. | Baseline |
| Microbiological sample | Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level | The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus. | Baseline |
| Clinical attachment level | The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gazi University Faculty of Dentistry | Ankara | 06490 | Turkey (Türkiye) | |||
| Tuğba Şahin |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| D005502 | Food |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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|
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| AOÇ Kefir | Dietary Supplement | AOÇ Kefir |
|
| Food without additional food supplements | Other | Food without additional food supplements |
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| 1st month |
| Microbiological sample | Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola. | 3rd month |
| Plaque index | It is an index that shows the amount of microbial dental plaque on the teeth. | Baseline |
| Plaque index | It is an index that shows the amount of microbial dental plaque on the teeth. | 1st month |
| Plaque index | It is an index that shows the amount of microbial dental plaque on the teeth. | 3rd month |
| Bleeding on probing | Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus. | Baseline |
| Bleeding on probing | Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus. | 1st month |
| Bleeding on probing | Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus. | 3rd month |
| 1st month |
| Clinical attachment level | The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus. | 3rd month |
| Ankara |
| 06560 |
| Turkey (Türkiye) |