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The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.
The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.
Thirty chronic periodontitis patients were randomized into 2 groups. As adjunctive to MPT, Group 1 consumed 2×108 CFU/day of Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt while Group 2 natural yoghurt once daily for 28 days. Subgingival plaque samples were obtained from 2 periodontal sites with probing pocket depth (PPD) of 4≤PPD<7 mm via paper-points at baseline, 28th day, 3rd month. Samples were cultured to evaluate total viable count (TVC), the proportions of obligate anaerobes (OA) and Bifidobacterium species (B) (TVC%). The full-mouth recorded clinical parameters were plaque index, gingival index, PPD, bleeding on probing, and clinical attachment level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Natural yoghurt | Placebo Comparator | SRP+nature yogurt (Danone® yogurt, Luleburgaz, Türkiye) |
|
| Probiotic yoghurt | Experimental | SRP+probiotic containing yogurt (Danone Activia® Plain, Luleburgaz, Türkiye) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| probiotic or natural yoghurt | Dietary Supplement | Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt |
|
| Measure | Description | Time Frame |
|---|---|---|
| Probing Depth | Probing depth is defined as the distance from the free gingival margin to the bottom of the periodontal pocket. | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Gingival Index | Each of the buccal, mesial, lingual and distal surfaces of the gingival tissues is given a score of 0-3. (0 = Normal gingiva. 1 = Mild inflammation - slight change in color, slight edema. No bleeding on probing. 2. Moderate inflammation - redness, edema and glazing. Bleeding on probing. 3. Severe inflammation -marked redness and edema.) | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bahar Kuru, Prof. Dr. | Marmara University, Faculty of Dentistry, Department of Periodontology | Study Director |
| Hafize Öztürk Özener, Dr. | Marmara University, Faculty of Dentistry, Department of Periodontology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marmara University | Istanbul | Maltepe | 34854 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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Individuals and doctor were blinded to the study groups allocation. Before statistical analysis, the blind study coordinator broke the code to allocate the indivuals to the groups.
| SRP | Procedure | Scalling and root planing |
|
| Plaque Index | Each of the four surfaces of the teeth (buccal, lingual, mesial and distal) is given a score from 0-3. (0 = No plaque in the gingival area. 1 = A film of plaque adhering to the free gingival margin and adjacent area of the tooth. The plaque may only be recognized by running a probe across the tooth surface. 2 = Moderate accumulation of soft deposits within the gingival pocket, on the gingival margin and/or adjacent tooth surface, which can be seen by the naked eye. 3 = Abundance of soft matter within the gingival pocket and/or on the gingival margin and adjacent tooth surface. Tendency to spontaneous bleeding.) | 28 days |
| Bleeding on probing | Bleeding on probing is defined as presence of bleeding from gingival sulcus during the probing of this area via periodontal probe. | 28 days |
| Clinical attachment level | The distance from the cementoenamel junction to the bottom of the periodontal pocket. | 28 days |
| microbiological parameters | The number of obligate anaerobic bacteria and Bifidobacterium anaerobes | 28 days |
| D002908 |
| Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019602 |
| Food and Beverages |